PDB: 98225 件ウェブページステータス検索Chemie searchBIRD

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7NBW	Crystal structure of PqsR (MvfR) ligand-binding domain in complex with a pyridin agonist 分子名称: Transcriptional regulator MvfR, ~{N}-[3-(4-fluorophenyl)prop-2-ynyl]-2-(trifluoromethyl)pyridin-4-amine 著者 Schmelz, S, Blankenfeldt, W. 登録日 2021-01-28 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR. Eur.J.Med.Chem., 226, 2021
7LCV	Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein 分子名称: CHLORIDE ION, Factor H binding protein, Immunoglobulin heavy chain Fd fragment, ... 著者 Beernink, P.T, Sands, N. 登録日 2021-01-11 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site. Plos Pathog., 17, 2021
8EXG	Human Carbonic Anhydrase II bound N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-4-sulfamoylbenzamide 分子名称: (4S)-5-amino-4-{1,3-dioxo-4-[(2-{2-[2-(4-sulfamoylbenzamido)ethoxy]ethoxy}ethyl)amino]-1,3-dihydro-2H-isoindol-2-yl}-5-oxopentanoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
8EXC	Human Carbonic Anhydrase II bound tert-butyl (3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamate 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, N-(3-{4-[3-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)propoxy]butoxy}propyl)-4-sulfamoylbenzamide, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
8EJB	Bruton's tyrosine kinase in complex with 3-{[4-(1-acetylpiperidin-4-yl)phenyl]amino}-5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]pyrazine-2-carboxamide 分子名称: 1,2-ETHANEDIOL, 5-[(3R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide, CHLORIDE ION, ... 著者 Gajewski, S, Clifton, M.C. 登録日 2022-09-16 公開日 2023-02-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 141, 2023
8EMU	Human Carbonic Anhydrase II Heterobifunctional Degraders 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, N-(2-methoxyethyl)-4-sulfamoylbenzamide, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-09-28 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 66, 2023
8EYL	Human Carbonic Anhydrase II with Tert-butyl (2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamate 分子名称: 2-[[(2~{R})-1-azanyl-5-oxidanyl-1,5-bis(oxidanylidene)pentan-2-yl]carbamoyl]-6-[2-[2-[(4-sulfamoylphenyl)carbonylamino]ethoxy]ethylamino]benzoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-27 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
7LT1	Structure of the cGAS-like receptor human MB21D2 分子名称: Protein MB21D2, SULFATE ION 著者 Morehouse, B.R, Slavik, K.M, Kranzusch, P.J. 登録日 2021-02-18 公開日 2021-07-21 最終更新日 2021-09-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature, 597, 2021
7LT2	Structure of a dsRNA-sensing cGAS-like receptor from the beetle Tribolium castaneum 分子名称: MANGANESE (II) ION, Mab-21 domain-containing protein 著者 Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. 登録日 2021-02-18 公開日 2021-07-21 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature, 597, 2021
7LP1	Structure of Nedd4L WW3 domain 分子名称: E3 ubiquitin-protein ligase NEDD4-like, GLYCEROL, NITRATE ION 著者 Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. 登録日 2021-02-11 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
7LP3	Structure of Nedd4L WW3 domain 分子名称: Angiomotin, E3 ubiquitin-protein ligase NEDD4-like, SULFATE ION 著者 Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. 登録日 2021-02-11 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
7LP2	Structure of Nedd4L WW3 domain 分子名称: Angiomotin, E3 ubiquitin-protein ligase, GLYCEROL, ... 著者 Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. 登録日 2021-02-11 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release. J.Biol.Chem., 297, 2021
6D05	Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 2. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H. 登録日 2018-04-10 公開日 2018-06-20 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Cryo-EM structure of an essential Plasmodium vivax invasion complex. Nature, 559, 2018
7KJE	F96S epi-isozizaene synthase: complex with 3 Mg2+ and neridronate 分子名称: (6-azanyl-1-oxidanyl-1-phosphono-hexyl)phosphonic acid, MAGNESIUM ION, SULFATE ION, ... 著者 Ronnebaum, T.A, Gardner, S, Christianson, D.W. 登録日 2020-10-26 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry, 59, 2020
7KJB	Crystal structure of the EphA2 S897E/S901E mutant intracellular KD-SAM domains 分子名称: CESIUM ION, Ephrin type-A receptor 2 著者 Lechtenberg, B.C, Pasquale, E.B. 登録日 2020-10-26 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Nat Commun, 12, 2021
7KGV	Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form 分子名称: Monoclonal antibody Fab heavy chain, Monoclonal antibody Fab light chain, Sodium-coupled neutral amino acid transporter 9 著者 Lei, H, Mu, X, Hattne, J, Gonen, T. 登録日 2020-10-19 公開日 2020-12-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 A conformational change in the N terminus of SLC38A9 signals mTORC1 activation. Structure, 29, 2021
6D04	Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 1. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H. 登録日 2018-04-10 公開日 2018-06-20 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Cryo-EM structure of an essential Plasmodium vivax invasion complex. Nature, 559, 2018
7KVC	Cryo-EM structure of Mal de Rio Cuarto virus P9-1 viroplasm protein (decamer) 分子名称: p9-1 著者 Llauger, G, Melero, R, Monti, D, Sycz, G, Huck-Iriart, C, Cerutti, M.L, Klinke, S, Arranz, R, Carazo, J.M, Goldbaum, F.A, del Vas, M, Otero, L.H. 登録日 2020-11-27 公開日 2022-06-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers. Mbio, 14, 2023
7KVD	Cryo-EM structure of Mal de Rio Cuarto virus P9-1 viroplasm protein (dodecamer) 分子名称: p9-1 著者 Llauger, G, Melero, R, Monti, D, Sycz, G, Huck-Iriart, C, Cerutti, M.L, Klinke, S, Arranz, R, Carazo, J.M, Goldbaum, F.A, del Vas, M, Otero, L.H. 登録日 2020-11-27 公開日 2022-06-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers. Mbio, 14, 2023
7LAP	Crystal structure of aminoglycoside acetyltransferase AAC(3)-Xa 分子名称: Aminoglycoside N(3)-acetyltransferase, CHLORIDE ION, D(-)-TARTARIC ACID, ... 著者 Stogios, P.J, Skarina, T, Kim, Y, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-01-06 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
7N8E	PptT PAP(CoA) 9056 complex 分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ... 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2021-06-14 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J.Med.Chem., 65, 2022
7N04	Crystal structure of the apo F240 antibody fragment 分子名称: Fab F240 heavy chain, Fab F240 light chain, alpha-D-glucopyranose 著者 Cook, J.D, Lee, J.E. 登録日 2021-05-25 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.70000517 Å) 主引用文献 Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies. Commun Biol, 5, 2022
1A4U	ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS 分子名称: ALCOHOL DEHYDROGENASE 著者 Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. 登録日 1998-02-05 公開日 1999-02-16 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution. J.Mol.Biol., 282, 1998
3RC1	Crystal Structure of KijD10, a 3-ketoreductase from Actinomadura kijaniata incomplex with NADP and TDP-benzene 分子名称: 1,2-ETHANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phenoxy)phosphoryl]oxy}phosphoryl]thymidine, CHLORIDE ION, ... 著者 Holden, H.M, Kubiak, R.L. 登録日 2011-03-30 公開日 2011-06-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Combined Structural and Functional Investigation of a C-3''-Ketoreductase Involved in the Biosynthesis of dTDP-l-Digitoxose. Biochemistry, 50, 2011
7N5U	ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21) 分子名称: DNA Strain II, DNA Strand I, ZINC ION, ... 著者 Horton, J.R, Ren, R, Cheng, X. 登録日 2021-06-06 公開日 2022-06-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J.Biol.Chem., 299, 2023

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