8EXG

Human Carbonic Anhydrase II bound N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-4-sulfamoylbenzamide

Summary for 8EXG

Entry DOI	10.2210/pdb8exg/pdb
Related	8EMU 8EXC
Descriptor	Carbonic anhydrase 2, ZINC ION, (4S)-5-amino-4-{1,3-dioxo-4-[(2-{2-[2-(4-sulfamoylbenzamido)ethoxy]ethoxy}ethyl)amino]-1,3-dihydro-2H-isoindol-2-yl}-5-oxopentanoic acid, ... (5 entities in total)
Functional Keywords	targeted protein degrader, protac, metalloenzyme, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30281.79
Authors	Kohlbrand, A.J.,O'Herin, C.B. (deposition date: 2022-10-25, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	O'Herin, C.B.,Moriuchi, Y.W.,Bemis, T.A.,Kohlbrand, A.J.,Burkart, M.D.,Cohen, S.M. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023 Cited by PubMed: 36735827 DOI: 10.1021/acs.jmedchem.2c01843 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation