8EXC

Human Carbonic Anhydrase II bound tert-butyl (3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamate

Summary for 8EXC

Entry DOI	10.2210/pdb8exc/pdb
Related	8EMU
Descriptor	Carbonic anhydrase 2, N-(3-{4-[3-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)propoxy]butoxy}propyl)-4-sulfamoylbenzamide, ZINC ION, ... (5 entities in total)
Functional Keywords	targeted protein degrader, protac, metalloenzyme, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30319.88
Authors	Kohlbrand, A.J.,O'Herin, C.B. (deposition date: 2022-10-25, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	O'Herin, C.B.,Moriuchi, Y.W.,Bemis, T.A.,Kohlbrand, A.J.,Burkart, M.D.,Cohen, S.M. Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023 Cited by PubMed: 36735827 DOI: 10.1021/acs.jmedchem.2c01843 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation