7KJE
F96S epi-isozizaene synthase: complex with 3 Mg2+ and neridronate
Summary for 7KJE
| Entry DOI | 10.2210/pdb7kje/pdb |
| Descriptor | epi-isozizaene synthase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | terpene cyclase, complex, bisphosphonate inhibitor, risedronate, lyase |
| Biological source | Streptomyces coelicolor |
| Total number of polymer chains | 1 |
| Total formula weight | 44102.04 |
| Authors | Ronnebaum, T.A.,Gardner, S.,Christianson, D.W. (deposition date: 2020-10-26, release date: 2020-12-16, Last modification date: 2023-10-18) |
| Primary citation | Ronnebaum, T.A.,Gardner, S.M.,Christianson, D.W. An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry, 59:4744-4754, 2020 Cited by PubMed: 33270439DOI: 10.1021/acs.biochem.0c00876 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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