Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 2.

Summary for 6D05

EMDB information7785
DescriptorTransferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, putative, ... (7 entities in total)
Functional Keywordsmalaria, plasmodium vivax, reticulocyte, invasion, cell invasion
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight499868.62
Gruszczyk, J.,Huang, R.K.,Hong, C.,Yu, Z.,Tham, W.H. (deposition date: 2018-04-10, release date: 2018-06-20, Last modification date: 2018-07-11)
Primary citation
Gruszczyk, J.,Huang, R.K.,Chan, L.J.,Menant, S.,Hong, C.,Murphy, J.M.,Mok, Y.F.,Griffin, M.D.W.,Pearson, R.D.,Wong, W.,Cowman, A.F.,Yu, Z.,Tham, W.H.
Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559:135-139, 2018
PubMed: 29950717 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0249-1
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers402.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures