6D05

Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 2.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transferrin receptor protein 1	polymer	659	73940.5	2	UniProt (P02786) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB	Homo sapiens (Human)	Trfr,T9,p90
2	C, D	Serotransferrin	polymer	698	77153.9	2	UniProt (P02787) Pfam (PF00405) In PDB	Homo sapiens (Human)	Transferrin,Beta-1 metal-binding globulin,Siderophilin
3	E, F	Reticulocyte binding protein 2, putative	polymer	820	96798.5	2	UniProt (A5K736) In PDB	Plasmodium vivax
4	G, H, I, J, K...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
5	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	C, D	FE (III) ION	non-polymer		55.8	4	Chemie (FE)
8	C, D	CARBONATE ION	non-polymer		60.0	4	Chemie (CO3)

Sequence modifications

A, B: 121 - 760 (UniProt: P02786)

PDB	External Database	Details
Ala 102	-	expression tag
Asp 103	-	expression tag
Pro 104	-	expression tag
His 105	-	expression tag
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
Ser 111	-	expression tag
Ser 112	-	expression tag
Gly 113	-	expression tag
Ile 114	-	expression tag
Glu 115	-	expression tag
Gly 116	-	expression tag
Arg 117	-	expression tag
Gly 118	-	expression tag
Glu 119	-	expression tag
Phe 120	-	expression tag
Ser 142	Gly 142	variant

C, D: -18 - 679 (UniProt: P02787)

PDB	External Database	Details
Val 429	Ile 448	variant

E, F: 155 - 969 (UniProt: A5K736)

PDB	External Database	Details
Gly 150	-	expression tag
Ala 151	-	expression tag
Met 152	-	expression tag
Gly 153	-	expression tag
Ser 154	-	expression tag
Ser 168	Ile 14	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	495785.7
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	14
	Total formula weight	1428.4
All*	Total formula weight	499760.5

*Water molecules are not included.