Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 1.

Summary for 6D04

EMDB information7784
DescriptorTransferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, putative, ... (8 entities in total)
Functional Keywordsmalaria, plasmodium vivax, reticulocyte, invasion, cell invasion
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight499760.53
Gruszczyk, J.,Huang, R.K.,Hong, C.,Yu, Z.,Tham, W.H. (deposition date: 2018-04-10, release date: 2018-06-20, Last modification date: 2020-07-29)
Primary citation
Gruszczyk, J.,Huang, R.K.,Chan, L.J.,Menant, S.,Hong, C.,Murphy, J.M.,Mok, Y.F.,Griffin, M.D.W.,Pearson, R.D.,Wong, W.,Cowman, A.F.,Yu, Z.,Tham, W.H.
Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559:135-139, 2018
PubMed: 29950717 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0249-1
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers40 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-08-12