7UDZ
 
 | | Designed pentameric proton channel LQLL | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed pentameric proton channel LQLL | | 著者 | Kratochvil, H.T, Thomaston, J.L, Mravic, M, Nicoludis, J.M, Liu, L, DeGrado, W.F. | | 登録日 | 2022-03-20 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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3BAR
 | | Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP | | 分子名称: | Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE | | 著者 | Liu, Y, Bello, A.M, Poduch, E, Lau, W, Kotra, L.P, Pai, E.F. | | 登録日 | 2007-11-08 | | 公開日 | 2008-01-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase.
J.Med.Chem., 51, 2008
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7UDX
 | | Designed pentameric proton channel QLQL | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, De novo designed pentameric proton channel QLQL | | 著者 | Kratochvil, H.T, Thomaston, J.L, Liu, L, DeGrado, W.F. | | 登録日 | 2022-03-20 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Transient water wires mediate selective proton transport in designed channel proteins.
Nat.Chem., 15, 2023
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1QPQ
 | | Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target | | 分子名称: | QUINOLINATE PHOSPHORIBOSYLTRANSFERASE, QUINOLINIC ACID, SULFATE ION | | 著者 | Sharma, V, Grubmeyer, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 1998-11-20 | | 公開日 | 1998-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
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1QPR
 | | QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP | | 分子名称: | 1-O-[(R)-hydroxy(phosphonomethyl)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose, MANGANESE (II) ION, PHTHALIC ACID, ... | | 著者 | Sharma, V, Grubmeyer, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 1998-10-17 | | 公開日 | 1998-10-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Structure, 6, 1998
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1QPN
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1QPO
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5NJG
 | | Structure of an ABC transporter: part of the structure that could be built de novo | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | | 登録日 | 2017-03-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
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6Z1L
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6Z1K
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1XL3
 | | Complex structure of Y.pestis virulence Factors YopN and TyeA | | 分子名称: | Secretion control protein, protein type A | | 著者 | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | | 登録日 | 2004-09-30 | | 公開日 | 2005-03-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
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3TQ2
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1XKP
 | | Crystal structure of the virulence factor YopN in complex with its heterodimeric chaperone SycN-YscB | | 分子名称: | Chaperone protein sycN, Chaperone protein yscB, putative membrane-bound Yop targeting protein YopN | | 著者 | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | | 登録日 | 2004-09-29 | | 公開日 | 2005-03-22 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
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1M3W
 | | Crystal Structure of a Molecular Maquette Scaffold | | 分子名称: | H10H24, MERCURY (II) ION | | 著者 | Huang, S.S, Gibney, B.R, Stayrook, S.E, Dutton, P.L, Lewis, M. | | 登録日 | 2002-07-01 | | 公開日 | 2003-02-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | X-ray Structure of a Maquette Scaffold
J.Mol.Biol., 326, 2003
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1EYZ
 | | STRUCTURE OF ESCHERICHIA COLI PURT-ENCODED GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE COMPLEXED WITH MG AND AMPPNP | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Thoden, J.B, Firestine, S, Nixon, A, Benkovic, S.J, Holden, H.M. | | 登録日 | 2000-05-09 | | 公開日 | 2000-08-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
Biochemistry, 39, 2000
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2MG4
 | | Computational design and experimental verification of a symmetric protein homodimer | | 分子名称: | Computational designed homodimer | | 著者 | Mou, Y, Huang, P.S, Hsu, F.C, Huang, S.J, Mayo, S.L. | | 登録日 | 2013-10-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Computational design and experimental verification of a symmetric protein homodimer.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4IGN
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1GAR
 | | TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION | | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID | | 著者 | Wilson, I.A, Klein, C, Chen, P, Arevalo, J.H. | | 登録日 | 1994-12-08 | | 公開日 | 1995-07-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
J.Mol.Biol., 249, 1995
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1G8M
 | | CRYSTAL STRUCTURE OF AVIAN ATIC, A BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME IN PURINE BIOSYNTHESIS AT 1.75 ANG. RESOLUTION | | 分子名称: | AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE, GUANOSINE-5'-MONOPHOSPHATE, POTASSIUM ION | | 著者 | Greasley, S.E, Horton, P, Beardsley, G.P, Benkovic, S.J, Wilson, I.A. | | 登録日 | 2000-11-17 | | 公開日 | 2001-04-27 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
Nat.Struct.Biol., 8, 2001
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1GPH
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4IH3
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8FXQ
 | | The Crystal Sturucture of Rhizopuspepsin with a bound modified peptide inhibitor generated by de novo drug design. | | 分子名称: | ALA-CYS-VAL-LYS, CYCLOHEXANE, Rhizopuspepsin, ... | | 著者 | Satyshur, K.A, Rich, D.H, Ripka, A.S. | | 登録日 | 2023-01-25 | | 公開日 | 2023-02-08 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Aspartic protease inhibitors designed from computer-generated templates bind as predicted.
Org Lett, 3, 2001
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2QAF
 | | Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-iodo-UMP | | 分子名称: | Orotidine 5' monophosphate decarboxylase, SULFATE ION, URIDINE-5'-MONOPHOSPHATE | | 著者 | Liu, Y, Lau, W, Bello, A.M, Kotra, L.P, Hui, R, Pai, E.F. | | 登録日 | 2007-06-15 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase
J.Med.Chem., 51, 2008
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2NDL
 | | NMR solution structure of PawS Derived Peptide 22 (PDP-22) | | 分子名称: | PawS derived peptide | | 著者 | Franke, B, Jayasena, A.S, Fisher, M.F, Swedberg, J.E, Taylor, N.L, Mylne, J.S, Rosengren, K. | | 登録日 | 2016-07-17 | | 公開日 | 2016-12-07 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).
Biopolymers, 106, 2016
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2WM1
 | | The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis | | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE, GLYCEROL, ... | | 著者 | Garavaglia, S, Perozzi, S, Galeazzi, L, Raffaelli, N, Rizzi, M. | | 登録日 | 2009-06-29 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | The Crystal Structure of Human Alpha-Amino-Beta-Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3-Dihydroxyacetonephosphate Suggests a Regulatory Link between Nad Synthesis and Glycolysis
FEBS J., 276, 2009
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