1GAR

TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION

Summary for 1GAR

• Entry DOI: 10.2210/pdb1gar/pdb
• Descriptor: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID (3 entities in total)
• Functional Keywords: transferase (formyl)
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 47963.85

Authors

Wilson, I.A.,Klein, C.,Chen, P.,Arevalo, J.H. (deposition date: 1994-12-08, release date: 1995-07-10, Last modification date: 2024-02-07)

• Primary citation: Klein, C.,Chen, P.,Arevalo, J.H.,Stura, E.A.,Marolewski, A.,Warren, M.S.,Benkovic, S.J.,Wilson, I.A.; Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.; J.Mol.Biol., 249:153-175, 1995; PubMed: 7776369; DOI: 10.1006/jmbi.1995.0286

Experimental method

X-RAY DIFFRACTION (1.96 Å)