8TBQ
 
 | | The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... | | 著者 | van der Horst, E.H, Mukherjee, A, Thisted, T. | | 登録日 | 2023-06-29 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | | 主引用文献 | VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response.
Nat Commun, 15, 2024
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6IGO
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6IGT
 | | MPZL1 mutant - V145G, Q146K, P147T and G148S | | 分子名称: | Myelin protein zero-like protein 1 | | 著者 | Yu, T. | | 登録日 | 2018-09-26 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | | 主引用文献 | Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1
Biochem. Biophys. Res. Commun., 506, 2018
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6IGW
 | | MPZL1 mutant - S86G, V145G, Q146K,P147T,G148S | | 分子名称: | Myelin protein zero-like protein 1 | | 著者 | Yu, T. | | 登録日 | 2018-09-26 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1
Biochem. Biophys. Res. Commun., 506, 2018
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4DFH
 | | Crystal structure of cell adhesion molecule nectin-2/CD112 variable domain | | 分子名称: | Poliovirus receptor-related protein 2 | | 著者 | Liu, J, Qian, X, Chen, Z, Xu, X, Gao, F, Zhang, S, Zhang, R, Qi, J, Gao, G.F, Yan, J. | | 登録日 | 2012-01-23 | | 公開日 | 2012-06-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226
J.Immunol., 188, 2012
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8TBB
 | | F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F9S Fab heavy chain, F9S Fab light chain, ... | | 著者 | Oganesyan, V, van Dyk, N, Mazor, Y, Yang, C. | | 登録日 | 2023-06-28 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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5MJ1
 | | Extracellular domain of human CD83 - rhombohedral crystal form | | 分子名称: | CD83 antigen, DI(HYDROXYETHYL)ETHER | | 著者 | Klingl, S, Egerer-Sieber, C, Schmid, B, Weiler, S, Muller, Y.A. | | 登録日 | 2016-11-29 | | 公開日 | 2017-03-29 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83.
J. Mol. Biol., 429, 2017
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8TFT
 | | Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, ... | | 著者 | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Yang, C. | | 登録日 | 2023-07-11 | | 公開日 | 2024-08-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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5MJ2
 | | Extracellular domain of human CD83 - rhombohedral crystal form after UV-RIP (S-SAD data) | | 分子名称: | CD83 antigen, DI(HYDROXYETHYL)ETHER | | 著者 | Klingl, S, Egerer-Sieber, C, Schmid, B, Weiler, S, Muller, Y.A. | | 登録日 | 2016-11-29 | | 公開日 | 2017-03-29 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83.
J. Mol. Biol., 429, 2017
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5N2F
 | | Structure of PD-L1/small-molecule inhibitor complex | | 分子名称: | 4-[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-2,5-bis(fluoranyl)phenyl]methylamino]-3-oxidanylidene-butanoic acid, Programmed cell death 1 ligand 1 | | 著者 | Guzik, K, Zak, K.M, Grudnik, P, Dubin, G, Holak, T.A. | | 登録日 | 2017-02-07 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
J. Med. Chem., 60, 2017
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5MJ0
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5NIU
 | | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | | 分子名称: | (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, Programmed cell death 1 ligand 1 | | 著者 | Zak, K.M, Grudnik, P, Skalniak, L, Dubin, G, Holak, T.A. | | 登録日 | 2017-03-27 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Oncotarget, 8, 2017
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6ISA
 | | mCD226 | | 分子名称: | CD226 antigen | | 著者 | Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F. | | 登録日 | 2018-11-16 | | 公開日 | 2018-12-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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5MIX
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8U31
 | | Crystal structure of PD-1 in complex with a Fab | | 分子名称: | Fab heavy chain, Fab light chain, GLYCEROL, ... | | 著者 | Sun, D, Masureel, M. | | 登録日 | 2023-09-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
Mabs, 16, 2024
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8U32
 | | Crystal structure of PD-1 in complex with a Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | | 著者 | Sun, D, Masureel, M. | | 登録日 | 2023-09-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability.
Mabs, 16, 2024
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6ISB
 | | crystal structure of human CD226 | | 分子名称: | CD226 antigen | | 著者 | Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F. | | 登録日 | 2018-11-16 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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8TE5
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5LVE
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8U0Y
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6HIG
 | | hPD-1/NBO1a Fab complex | | 分子名称: | Heavy Chain, Light Chain, Programmed cell death protein 1 | | 著者 | Loredo-Varela, J.L, Fenwick, C, Pantaleo, G, Weissenhorn, W. | | 登録日 | 2018-08-29 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.
J.Exp.Med., 216, 2019
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5N2D
 | | Structure of PD-L1/small-molecule inhibitor complex | | 分子名称: | Programmed cell death 1 ligand 1, ~{N}-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenyl-phenyl)methoxy]phenyl]methylamino]ethyl]ethanamide | | 著者 | Guzik, K, Zak, K.M, Grudnik, P, Dubin, G, Holak, T.A. | | 登録日 | 2017-02-07 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
J. Med. Chem., 60, 2017
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6ISC
 | | complex structure of mCD226-ecto and hCD155-D1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD226 antigen, Poliovirus receptor | | 著者 | Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F. | | 登録日 | 2018-11-16 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6J14
 | | Complex structure of GY-14 and PD-1 | | 分子名称: | GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1 | | 著者 | Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | | 登録日 | 2018-12-27 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
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6J15
 | | Complex structure of GY-5 Fab and PD-1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ... | | 著者 | Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | | 登録日 | 2018-12-27 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
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