6HIG

hPD-1/NBO1a Fab complex

Summary for 6HIG

Entry DOI	10.2210/pdb6hig/pdb
Descriptor	Heavy Chain, Light Chain, Programmed cell death protein 1, ... (4 entities in total)
Functional Keywords	non-blocking antibody, pd-1/pd-l1 pathway, anti-pd-1 antibody, tumor clearance, immune system
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	61731.74
Authors	Loredo-Varela, J.L.,Fenwick, C.,Pantaleo, G.,Weissenhorn, W. (deposition date: 2018-08-29, release date: 2019-06-05, Last modification date: 2024-01-17)
Primary citation	Fenwick, C.,Loredo-Varela, J.L.,Joo, V.,Pellaton, C.,Farina, A.,Rajah, N.,Esteves-Leuenberger, L.,Decaillon, T.,Suffiotti, M.,Noto, A.,Ohmiti, K.,Gottardo, R.,Weissenhorn, W.,Pantaleo, G. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J.Exp.Med., 216:1525-1541, 2019 Cited by PubMed: 31123083 DOI: 10.1084/jem.20182359 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation