7KQX
 
 | | MIF Y99C homotrimeric mutant | | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | | 著者 | Manjula, R, Georgios, P, Lolis, E.J. | | 登録日 | 2020-11-18 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
Front Mol Biosci, 9, 2022
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7E45
 | | Crystal structure of compound 7 bound to MIF | | 分子名称: | (2R)-7-[(2R,3R,4R,5S,6S)-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(4-methoxy-3-oxidanyl-phenyl)-5-oxidanyl-2,3-dihydrochromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | | 著者 | Fan, C.P, Yang, L. | | 登録日 | 2021-02-10 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.433 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7E47
 | | Crystal structure of compound 6 bound to MIF | | 分子名称: | (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, CHLORIDE ION, Macrophage migration inhibitory factor | | 著者 | Fan, C.P, Yang, L, Guo, D.Y. | | 登録日 | 2021-02-10 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7E4A
 | | Crystal structure of MIF bound to compound 13 | | 分子名称: | CHLORIDE ION, Flavoxate, Macrophage migration inhibitory factor, ... | | 著者 | Fa, C.P, Guo, D.Y, Yang, L. | | 登録日 | 2021-02-11 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.475 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7E4B
 | | Crystal structure of MIF bound to compound 5 | | 分子名称: | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | | 登録日 | 2021-02-11 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.772 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7E4C
 | | Crystal structure of MIF bound to compound11 | | 分子名称: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CHLORIDE ION, Macrophage migration inhibitory factor, ... | | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | | 登録日 | 2021-02-11 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.644 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7E49
 | | Crystal structure of MIF bound to compound10 | | 分子名称: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor | | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | | 登録日 | 2021-02-11 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.574 Å) | | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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7MRV
 | | F100A mutant structure of MIF2 (D-DT) | | 分子名称: | D-dopachrome decarboxylase, SULFATE ION | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-09 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7MRU
 | | Crystal structure of S62A MIF2 mutant | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-09 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7MSE
 | | High-resolution crystal structure of hMIF2 with tartrate at the active site | | 分子名称: | D-dopachrome decarboxylase, L(+)-TARTARIC ACID | | 著者 | Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-11 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7MW7
 | | Crystal structure of P1G mutant of D-dopachrome tautomerase | | 分子名称: | D-dopachrome decarboxylase, SODIUM ION, SULFATE ION | | 著者 | Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E. | | 登録日 | 2021-05-15 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
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7XTX
 | | High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate | | 分子名称: | 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | | 著者 | Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. | | 登録日 | 2022-05-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
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7XVX
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8DBB
 | | Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid | | 分子名称: | CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid | | 著者 | Parkins, A, Banumathi, S, Pantouris, G. | | 登録日 | 2022-06-14 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase.
Structure, 31, 2023
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8DQA
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8DQ6
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8AP3
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8CA0
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8IMR
 | | Structure of ligand-free human macrophage migration inhibitory factor | | 分子名称: | 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | | 著者 | Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. | | 登録日 | 2023-03-07 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
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8SON
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8SPN
 | | Crystal structure of macrophage migration inhibitory factor in complex with T614 | | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, Iguratimod, ... | | 著者 | Pantouris, G, Lolis, E. | | 登録日 | 2023-05-03 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med, 30, 2024
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8UR2
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8UR4
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8UZ4
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8VDY
 | | Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) | | 分子名称: | D-dopachrome decarboxylase | | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | | 登録日 | 2023-12-18 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
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