8CA0
Macrophage inhibitory factor (MIF) in complex with small molecule PAV174
Summary for 8CA0
| Entry DOI | 10.2210/pdb8ca0/pdb |
| NMR Information | BMRB: 34783 |
| Descriptor | Macrophage migration inhibitory factor, 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine (2 entities in total) |
| Functional Keywords | mif, oxmif, herpes, alzheimer's disease, protein binding |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 37444.73 |
| Authors | |
| Primary citation | Mueller-Schiffmann, A.,Torres, F.,Kitaygorodskyy, A.,Ramani, A.,Alatza, A.,Tschirner, S.,Prikulis, I.,Yu, S.,Dey, D.,Mallesh, S.,Prasad, D.,Solas, D.,Bader, V.,Rozemuller, A.,Wray, S.,Gopalakrishnan, J.,Riek, R.,Lingappa, V.R.,Korth, C. Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology To Be Published, |
| Experimental method | SOLUTION NMR |
Structure validation
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