7XTX

High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate

Summary for 7XTX

• Entry DOI: 10.2210/pdb7xtx/pdb
• Descriptor: Macrophage migration inhibitory factor, SULFATE ION, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: methotrexate, cytokine-inhibitor complex, cytokine/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 38767.90

Authors

Sugishima, K.,Noguchi, K.,Yohda, M.,Odaka, M.,Matsumura, H. (deposition date: 2022-05-18, release date: 2023-05-24, Last modification date: 2023-11-29)

• Primary citation: Sugishima, K.,Kariya, Y.,Ezawa, T.,Nagatoishi, S.,Tsumoto, K.,Shigeta, Y.,Noguchi, K.,Yohda, M.,Odaka, M.,Wakui, H.,Matsumura, H.; Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.28 Å)