7XTX
High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Macrophage migration inhibitory factor | polymer | 114 | 12355.1 | 3 | UniProt (P14174) Pfam (PF01187) In PDB | Homo sapiens (human) | MIF,Glycosylation-inhibiting factor,GIF,L-dopachrome isomerase,L-dopachrome tautomerase,Phenylpyruvate tautomerase |
2 | A, B, C | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
4 | A, C | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 3 | Chemie (IPA) | |||
5 | B | N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID | non-polymer | 455.4 | 1 | Chemie (MT1) | |||
6 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 37065.2 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 1702.7 | |
All* | Total formula weight | 38767.9 |