7XTX
High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Macrophage migration inhibitory factor | polymer | 114 | 12355.1 | 3 | UniProt (P14174) Pfam (PF01187) | Homo sapiens (human) | MIF,Glycosylation-inhibiting factor,GIF,L-dopachrome isomerase,L-dopachrome tautomerase,Phenylpyruvate tautomerase |
| 2 | D, K, Q, R (A, B, C) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | E, F, G, H, L... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 4 | I, U, V (A, C) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 3 | Chemie (IPA) | |||
| 5 | J (B) | N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID | non-polymer | 455.4 | 1 | Chemie (MT1) | |||
| 6 | W, X, Y (A, B, C) | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37065.2 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1702.7 | |
| All* | Total formula weight | 38767.9 |
