9BRX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9brx by Molmil](/molmil-images/mine/9brx) | SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 10 | 分子名称: | (4R)-N-(2,4-dimethylphenyl)-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-amine, Papain-like protease nsp3, SULFATE ION, ... | 著者 | Amporndanai, K, Zhao, B, Fesik, S.W. | 登録日 | 2024-05-11 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro) Acs Med.Chem.Lett., 2024
|
|
8YVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8yvw by Molmil](/molmil-images/mine/8yvw) | Crystal structure of D12N mutant of L-azetidine-2-carboxylate hydrolase | 分子名称: | (S)-2-haloacid dehalogenase, FORMIC ACID, IMIDAZOLE, ... | 著者 | Toyoda, M, Mizutani, K, Mikami, B, Wackett, L.P, Esaki, N, Kurihara, T. | 登録日 | 2024-03-29 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Research for the crystal structure of L-azetidine-2-carboxylate hydrolase To Be Published
|
|
9BKF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bkf by Molmil](/molmil-images/mine/9bkf) | |
8W04
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8w04 by Molmil](/molmil-images/mine/8w04) | |
8WQO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wqo by Molmil](/molmil-images/mine/8wqo) | Crystal structure of BRD4-BD1 bound with DI106 | 分子名称: | (3~{R})-6-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one, Isoform C of Bromodomain-containing protein 4 | 著者 | Cao, D, Xiong, B. | 登録日 | 2023-10-12 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Rational design and evaluation of BET-Aurora A dual-inhibitors for treatment of cancers To Be Published
|
|
9BKL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bkl by Molmil](/molmil-images/mine/9bkl) | |
8QRD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qrd by Molmil](/molmil-images/mine/8qrd) | OleP in complex with testosterone in high salt crystallization conditions | 分子名称: | Cytochrome P-450, FORMIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Fata, F, Costanzo, A, Freda, I, Gugole, E, Bulfaro, G, Barbizzi, L, Di Renzo, M, Savino, C, Vallone, B, Montemiglio, L.C. | 登録日 | 2023-10-06 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | OleP in complex with testosterone in high salt crystallization conditions To Be Published
|
|
8WYP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8wyp by Molmil](/molmil-images/mine/8wyp) | |
8XEY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8xey by Molmil](/molmil-images/mine/8xey) | The Crystal Structure of C-terminal kinase domain of RSK2 from Biortus | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ribosomal protein S6 kinase alpha-3 | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | 登録日 | 2023-12-13 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The Crystal Structure of C-terminal kinase domain of RSK2 from Biortus To Be Published
|
|
6LIT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lit by Molmil](/molmil-images/mine/6lit) | Estrogen-related receptor beta(ERR2) in complex with BPA | 分子名称: | 10-mer from Nuclear receptor coactivator 2, 4,4'-PROPANE-2,2-DIYLDIPHENOL, Steroid hormone receptor ERR2 | 著者 | Yao, B.Q, Li, Y. | 登録日 | 2019-12-13 | 公開日 | 2020-10-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta. J.Mol.Biol., 432, 2020
|
|
8YY8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8yy8 by Molmil](/molmil-images/mine/8yy8) | Fzd7 -Gs complex | 分子名称: | Frizzled-7, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B, Xu, L, Han, G.W, Xu, F. | 登録日 | 2024-04-03 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s . Cell Res., 31, 2021
|
|
6ZZ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zz0 by Molmil](/molmil-images/mine/6zz0) | |
9FS7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9fs7 by Molmil](/molmil-images/mine/9fs7) | Coxsackievirus A16 3C protease in C2 2 21 spacegroup | 分子名称: | Genome polyprotein | 著者 | Fairhead, M, Lithgo, R, MacLean, M, Bowesman-Jones, H, Aschenbrenner, J.C, Balcomb, B.H, Capkin, E, Chandran, A.V, Godoy, A.S, Marples, P.G, Fearon, D, von Delft, F, Koekemoer, L. | 登録日 | 2024-06-20 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Coxsackievirus A16 3C protease in C2 2 21 spacegroup To Be Published
|
|
6XZA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xza by Molmil](/molmil-images/mine/6xza) | E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification). | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2020-02-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome. Rna, 26, 2020
|
|
9BKP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bkp by Molmil](/molmil-images/mine/9bkp) | |
5CZK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5czk by Molmil](/molmil-images/mine/5czk) | Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea | 分子名称: | 1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea, Beta-glucuronidase | 著者 | Roberts, A.R, Wallace, B.R, Redinbo, M.R. | 登録日 | 2015-07-31 | 公開日 | 2015-10-14 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem.Biol., 22, 2015
|
|
9BOM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9bom by Molmil](/molmil-images/mine/9bom) | Crystal structure of reduced bovine trypsin, 25mM DTT-treated | 分子名称: | BENZAMIDINE, Cationic trypsin | 著者 | Zhou, D, Chen, L, Rose, J.P, Wang, B.C. | 登録日 | 2024-05-03 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of reduced bovine trypsin, 25mM DTT-treated To Be Published
|
|
6KZE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kze by Molmil](/molmil-images/mine/6kze) | The crystal structue of PDE10A complexed with 4d | 分子名称: | 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ... | 著者 | Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B. | 登録日 | 2019-09-24 | 公開日 | 2020-09-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.50003481 Å) | 主引用文献 | Novel Potent and Highly Selective Benzoimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for the Treatment of Pulmonary Arterial Hypertension To Be Published
|
|
8YHV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8yhv by Molmil](/molmil-images/mine/8yhv) | |
8XOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8xov by Molmil](/molmil-images/mine/8xov) | The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | 登録日 | 2024-01-02 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The Crystal Structure of N-terminal kinase domain of human RSK-1 from Biortus. To Be Published
|
|
9ASH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9ash by Molmil](/molmil-images/mine/9ash) | |
9EME
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9eme by Molmil](/molmil-images/mine/9eme) | AL amyloid fibril from the FOR103 light chain | 分子名称: | lambda 3 immunoglobulin light chain fragment, residues 2-116 | 著者 | Pfeiffer, P.B, Karimi-Farsijani, S, Kupfer, N, Schmidt, M, Faendrich, M. | 登録日 | 2024-03-08 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis. Nat Commun, 15, 2024
|
|
966C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 966c by Molmil](/molmil-images/mine/966c) | CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID | 分子名称: | CALCIUM ION, MMP-1, N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE, ... | 著者 | Lovejoy, B, Welch, A, Carr, S, Luong, C, Broka, C, Hendricks, R.T, Campbell, J, Walker, K, Martin, R, Van Wart, H, Browner, M.F. | 登録日 | 1998-08-07 | 公開日 | 1999-08-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors. Nat.Struct.Biol., 6, 1999
|
|
8QYI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qyi by Molmil](/molmil-images/mine/8qyi) | OleP in complex with lithocholic acid in high salt crystallization conditions | 分子名称: | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Cytochrome P-450, FORMIC ACID, ... | 著者 | Fata, F, Costanzo, A, Freda, I, Gugole, E, Bulfaro, G, Barbizzi, L, Di Renzo, M, Savino, C, Vallone, B, Montemiglio, L.C. | 登録日 | 2023-10-26 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | OleP in complex with lithocolic acid in high salt crystallization conditions To Be Published
|
|
6XY5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xy5 by Molmil](/molmil-images/mine/6xy5) | Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 5 | 分子名称: | 14-3-3 protein sigma, 3-bromanyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... | 著者 | Somsen, B.A, Ottmann, C. | 登録日 | 2020-01-29 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
|
|