8WQO

Crystal structure of BRD4-BD1 bound with DI106

Summary for 8WQO

• Entry DOI: 10.2210/pdb8wqo/pdb
• Descriptor: Isoform C of Bromodomain-containing protein 4, (3~{R})-6-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one (3 entities in total)
• Functional Keywords: inhibitor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15145.55

Authors

Cao, D.,Xiong, B. (deposition date: 2023-10-12, release date: 2024-07-24)

• Primary citation: Xiong, B.,Kaikai, L.,Cao, D.,Dong, G.; Rational design and evaluation of BET-Aurora A dual-inhibitors for treatment of cancers; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.13 Å)