8WQO
Crystal structure of BRD4-BD1 bound with DI106
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform C of Bromodomain-containing protein 4 | polymer | 124 | 14740.0 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 2 | B (A) | (3~{R})-6-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one | non-polymer | 405.5 | 1 | Chemie (X3L) | |||
| 3 | C (A) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 42 - 165 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14740.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 405.5 | |
| All* | Total formula weight | 15145.5 |
