8WYP

High Resolution Crystal Structure of Brd4 BD-1 in Complex with a Novel Inhibitor Precursor

Summary for 8WYP

• Entry DOI: 10.2210/pdb8wyp/pdb
• Descriptor: Bromodomain-containing protein 4, 3-bromanylimidazo[1,2-a]pyridin-6-amine (3 entities in total)
• Functional Keywords: brd4 inhibitor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15307.28

Authors

Liu, B.,Ma, X. (deposition date: 2023-10-31, release date: 2024-05-22)

• Primary citation: Ma, X.,Wang, M.,Wang, F.,Li, J.,Zhang, Z.,Zhu, J.,Liu, B.; High resolution crystal structure of BRD4-BD1 in complex with a novel inhibitor precursor.; Biochem.Biophys.Res.Commun., 690:149284-149284, 2024; PubMed: 38006801; DOI: 10.1016/j.bbrc.2023.149284

Experimental method

X-RAY DIFFRACTION (1.24 Å)