6KZE

The crystal structue of PDE10A complexed with 4d

Summary for 6KZE

• Entry DOI: 10.2210/pdb6kze/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, ZINC ION, ... (5 entities in total)
• Functional Keywords: pde10a inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 75794.62

Authors

Yang, Y.,Zhang, S.,Zhou, Q.,Huang, Y.-Y.,Guo, L.,Luo, H.-B. (deposition date: 2019-09-24, release date: 2020-09-30, Last modification date: 2023-11-22)

• Primary citation: Yang, Y.,Zhang, S.,Zhou, Q.,Huang, Y.-Y.,Huang, J.,Li, Z.,Gao, Y.,Wu, Y.,Wu, D.,Luo, H.-B.,Guo, L.; Novel Potent and Highly Selective Benzoimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for the Treatment of Pulmonary Arterial Hypertension; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.50003487525 Å)