PDB: 237423 件ウェブページステータス検索Chemie searchBIRD

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6DCA	Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. 分子名称: Fab heavy chain, Fab light chain, Microtubule-associated protein tau, ... 著者 Chukwu, J.E, Kong, X.-P. 登録日 2018-05-04 公開日 2019-03-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.599 Å) 主引用文献 Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein. MAbs, 11, 2019
6DCB	Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA 分子名称: 7SK snRNA methylphosphate capping enzyme, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Yang, Y, Eichhorn, C, Cascio, D, Feigon, J. 登録日 2018-05-04 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Structural basis of 7SK RNA 5'-gamma-phosphate methylation and retention by MePCE. Nat. Chem. Biol., 15, 2019
6DCC	Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA 分子名称: 7SK snRNA methylphosphate capping enzyme, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Yang, Y, Eichhorn, C, Cascio, D, Feigon, J. 登録日 2018-05-04 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of 7SK RNA 5'-gamma-phosphate methylation and retention by MePCE. Nat. Chem. Biol., 15, 2019
6DCD	Mycobacterium marinum cytochrome P450 CYP150A6 in the substrate-free form 分子名称: Cytochrome P450 150A6 Cyp150A6, PROTOPORPHYRIN IX CONTAINING FE 著者 Child, S.A, Bruning, J.B, Bell, S.G. 登録日 2018-05-05 公開日 2019-03-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum. Biochim Biophys Acta Gen Subj, 1863, 2019
6DCE	X-ray structure of FIP200 claw domain 分子名称: RB1-inducible coiled-coil protein 1, SULFATE ION 著者 Su, M.-Y, Hurley, J.H. 登録日 2018-05-05 公開日 2019-03-06 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol. Cell, 74, 2019
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-05-06 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6DCG	Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology 分子名称: (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. 登録日 2018-05-06 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett, 9, 2018
6DCH	Structure of isonitrile biosynthesis enzyme ScoE 分子名称: ACETATE ION, CHLORIDE ION, CHOLINE ION, ... 著者 Born, D.A, Drennan, C.L. 登録日 2018-05-07 公開日 2018-06-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase. Angew. Chem. Int. Ed. Engl., 57, 2018
6DCJ	LpoA N-terminal domain from Haemophilus influenzae; monoclinic form at 1.35 A resolution 分子名称: CHLORIDE ION, Penicillin-binding protein activator LpoA 著者 Vijayalakshmi, J, Saper, M.A. 登録日 2018-05-07 公開日 2019-05-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Crystal structures of the amino-terminal domain of LpoA from Escherichia coli and Haemophilus influenzae. Acta Crystallogr.,Sect.F, 75, 2019
6DCL	Crystal structure of UP1 bound to pri-miRNA-18a terminal loop 分子名称: 1,2-ETHANEDIOL, Heterogeneous nuclear ribonucleoprotein A1, RNA (5'-R(*AP*GP*UP*AP*GP*AP*UP*UP*AP*GP*C)-3') 著者 Kooshapur, H, Sattler, M. 登録日 2018-05-07 公開日 2018-06-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.497 Å) 主引用文献 Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1. Nat Commun, 9, 2018
6DCM	The atomic resolution crystal structure of Kringle 2 variant bound with EACA 分子名称: 6-AMINOHEXANOIC ACID, Plasminogen 著者 Ghanbarpour, A, Geiger, J. 登録日 2018-05-07 公開日 2019-05-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.031 Å) 主引用文献 The atomic resolution crystal structure of Kringle 2 variant bound with EACA To Be Published
6DCN	Bcl-xL complex with Beclin 1 BH3 domain T108pThr 分子名称: BCL-xl protein, Beclin-1 著者 Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D. 登録日 2018-05-07 公開日 2018-05-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.444 Å) 主引用文献 Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1. Autophagy, 15, 2019
6DCO	Bcl-xL complex with Beclin 1 BH3 domain T108D 分子名称: Bcl-2-like protein 1,Bcl-2-like protein 1, Beclin-1, CHLORIDE ION 著者 Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D. 登録日 2018-05-07 公開日 2018-05-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1. Autophagy, 15, 2019
6DCQ	Ectodomain of full length, wild type HIV-1 glycoprotein clone PC64M18C043 in complex with PGT151 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rantalainen, K. 登録日 2018-05-08 公開日 2018-06-27 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep, 23, 2018
6DCR	E. coli PriA helicase winged helix domain deletion protein 分子名称: Primosomal protein N', SULFATE ION, ZINC ION 著者 Satyshur, K.A, Windgassen, T.A, Keck, J.L. 登録日 2018-05-08 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DCS	Stage III sporulation protein AF (SpoIIIAF) 分子名称: SULFATE ION, Stage III sporulation protein AF 著者 Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A. 登録日 2018-05-08 公開日 2018-07-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and biochemical characterization of SpoIIIAF, a component of a sporulation-essential channel in Bacillus subtilis. J. Struct. Biol., 204, 2018
6DCU	Crystal structure of PPAR gamma co-crystallized with nTZDpa 分子名称: 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Mou, T.C, Chrisman, I.M, Hughes, T.S, Sprang, S.R. 登録日 2018-05-08 公開日 2019-05-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of PPAR gamma in complex with NMP422 To Be Published
6DCV	Crystal structure of human anti-tau antibody CBTAU-27.1 分子名称: GLYCEROL, Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab 著者 Zhu, X, Zhang, H, Wilson, I.A. 登録日 2018-05-08 公開日 2018-06-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities. Acta Neuropathol Commun, 6, 2018
6DCW	Crystal structure of human anti-tau antibody CBTAU-27.1 Fab in complex with a human tau peptide 分子名称: Heavy chain of CBTAU27.1 Fab, Light chain of CBTAU27.1 Fab, tau peptide 著者 Zhu, X, Zhang, H, Wilson, I.A. 登録日 2018-05-08 公開日 2018-06-06 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities. Acta Neuropathol Commun, 6, 2018
6DCX	iASPP-PP-1c structure and targeting of p53 分子名称: RelA-associated inhibitor, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 著者 Glover, J.N.M, Zhou, Y, Edwards, R.A. 登録日 2018-05-08 公開日 2019-05-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.408 Å) 主引用文献 Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure, 27, 2019
6DCY	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid 分子名称: 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-05-08 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
6DCZ	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid 分子名称: 3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Cohen, S.M. 登録日 2018-05-08 公開日 2018-11-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61, 2018
6DD0	Crystal structure of VIM-2 complexed with compound 8 分子名称: ACETATE ION, Beta-lactamase class B VIM-2, ZINC ION, ... 著者 Pemberton, O.A, Chen, Y. 登録日 2018-05-08 公開日 2019-05-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62, 2019
6DD1	Crystal structure of VIM-2 complexed with compound 14 分子名称: ACETATE ION, Beta-lactamase class B VIM-2, ZINC ION, ... 著者 Pemberton, O.A, Chen, Y. 登録日 2018-05-08 公開日 2019-05-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62, 2019
6DD2	Crystal structure of Selaginella moellendorffii HCT 分子名称: Probable hydroxycinnamoyl transferase 著者 Levsh, O, Chiang, Y.C, Lam, C.K, Wang, Y, Weng, J.K. 登録日 2018-05-09 公開日 2018-10-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9056 Å) 主引用文献 Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT). PLoS Comput. Biol., 14, 2018

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