6DD1

Crystal structure of VIM-2 complexed with compound 14

Summary for 6DD1

• Entry DOI: 10.2210/pdb6dd1/pdb
• Descriptor: Beta-lactamase class B VIM-2, ZINC ION, [(quinolin-8-yl)methyl]phosphonic acid, ... (5 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 52908.27

Authors

Pemberton, O.A.,Chen, Y. (deposition date: 2018-05-08, release date: 2019-05-08, Last modification date: 2023-10-11)

• Primary citation: Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y.; Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.; J.Med.Chem., 62:8480-8496, 2019; PubMed: 31483651; DOI: 10.1021/acs.jmedchem.9b00728

Experimental method

X-RAY DIFFRACTION (1.7 Å)