6DD0
Crystal structure of VIM-2 complexed with compound 8
Summary for 6DD0
| Entry DOI | 10.2210/pdb6dd0/pdb |
| Descriptor | Beta-lactamase class B VIM-2, ZINC ION, [(5,7-difluoro-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (5 entities in total) |
| Functional Keywords | beta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 2 |
| Total formula weight | 52567.87 |
| Authors | Pemberton, O.A.,Chen, Y. (deposition date: 2018-05-08, release date: 2019-05-08, Last modification date: 2023-10-11) |
| Primary citation | Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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