6DCW

Crystal structure of human anti-tau antibody CBTAU-27.1 Fab in complex with a human tau peptide

Summary for 6DCW

DescriptorLight chain of CBTAU27.1 Fab, Heavy chain of CBTAU27.1 Fab, tau peptide, ... (4 entities in total)
Functional Keywordstau, fab, naturally occurring human antibody, common motif, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight51487.27
Authors
Zhu, X.,Zhang, H.,Wilson, I.A. (deposition date: 2018-05-08, release date: 2018-06-06, Last modification date: 2018-06-13)
Primary citation
Apetri, A.,Crespo, R.,Juraszek, J.,Pascual, G.,Janson, R.,Zhu, X.,Zhang, H.,Keogh, E.,Holland, T.,Wadia, J.,Verveen, H.,Siregar, B.,Mrosek, M.,Taggenbrock, R.,Ameijde, J.,Inganas, H.,van Winsen, M.,Koldijk, M.H.,Zuijdgeest, D.,Borgers, M.,Dockx, K.,Stoop, E.J.M.,Yu, W.,Brinkman-van der Linden, E.C.,Ummenthum, K.,van Kolen, K.,Mercken, M.,Steinbacher, S.,de Marco, D.,Hoozemans, J.J.,Wilson, I.A.,Koudstaal, W.,Goudsmit, J.
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6:43-43, 2018
PubMed: 29855358 (PDB entries with the same primary citation)
DOI: 10.1186/s40478-018-0543-z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.216200.8%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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