6GCD
| |
4DGG
| c-SRC kinase domain in complex with RM-1-176 | 分子名称: | 3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | 著者 | Merritt, E.A, Larson, E.T. | 登録日 | 2012-01-25 | 公開日 | 2012-10-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol., 9, 2013
|
|
5FTG
| Human choline kinase a1 in complex with compound 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1- yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N- dimethyl-pyridin-4-amine (compound 10a) | 分子名称: | 1,2-ETHANEDIOL, 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1-yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N-dimethyl-pyridin-4-amine, CHOLINE KINASE ALPHA | 著者 | Schiaffino-Ortega, S, Baglioni, E, Mariotto, E, Bortolozzi, R, Serran-Aguilera, L, Rios-Marco, P, Carrasco-Jimenez, M.P, Gallo, M.A, Hurtado-Guerrero, R, Marco, C, Basso, G, Viola, G, Entrena, A, Lopez-Cara, L.C. | 登録日 | 2016-01-13 | 公開日 | 2016-03-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Design, Synthesis, Crystallization and Biological Evaluation of New Symmetrical Biscationic Compounds as Selective Inhibitors of Human Choline Kinase Alpha1 (Chokalpha1) Sci.Rep., 6, 2016
|
|
6CHI
| Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide | 分子名称: | 3-hydroxy-17-(3-pyridyl)-androst-5,16-dien-6-amide, PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase | 著者 | Scott, E.E. | 登録日 | 2018-02-22 | 公開日 | 2018-06-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | 主引用文献 | Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2. J. Med. Chem., 61, 2018
|
|
1HCX
| Choline binding domain of the major autolysin (C-LytA) from Streptococcus pneumoniae | 分子名称: | 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride, CHOLINE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | 著者 | Fernandez-Tornero, C, Lopez, R, Garcia, E, Gimenez-Gallego, G, Romero, A. | 登録日 | 2001-05-10 | 公開日 | 2001-11-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A Novel Solenoid Fold in the Cell Wall Anchoring Domain of the Pneumococcal Virulence Factor Lyta Nat.Struct.Biol., 8, 2001
|
|
1H7G
| |
3NOD
| MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND PRODUCT ANALOGUE L-THIOCITRULLINE | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, L-THIOCITRULLINE, NITRIC OXIDE SYNTHASE, ... | 著者 | Crane, B.R, Arvai, A.S, Getzoff, E.D, Stuehr, D.J, Tainer, J.A. | 登録日 | 1998-03-06 | 公開日 | 1999-03-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science, 279, 1998
|
|
1CY1
| COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'PTPTPT | 分子名称: | DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... | 著者 | Feinberg, H, Changela, A, Mondragon, A. | 登録日 | 1999-08-31 | 公開日 | 2000-03-03 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
|
|
6FSZ
| Structure of the nuclear RNA exosome | 分子名称: | ATP-dependent RNA helicase DOB1, Exosome complex component CSL4, Exosome complex component MTR3, ... | 著者 | Schuller, J.M, Falk, S, Conti, E. | 登録日 | 2018-02-20 | 公開日 | 2018-03-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
|
|
6FUG
| Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol | 分子名称: | 3-[[3-[[3-(aminomethyl)phenyl]amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenol, Complement factor D | 著者 | Mac Sweeney, A, Ostermann, N, Vulpetti, A, Maibaum, J, Erbel, P, Lorthiois, E, Yoon, T, Randl, S, Ruedisser, S. | 登録日 | 2018-02-27 | 公開日 | 2018-06-06 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9, 2018
|
|
1H7H
| |
5A7E
| Crystallographic Structural Determination of a Trigonal Laccase from Coriolopsis Gallica (CgL) to 1.5 A resolution | 分子名称: | ACETATE ION, COPPER (II) ION, CORIOLOPSIS GALLICA LACCASE, ... | 著者 | Ruiz-Arellano, R.R, Diaz, A, Ayala, M, De la Mora, E, Rudino-Pinera, E. | 登録日 | 2015-07-03 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Metal Site Delocalization Observed in a Model Multicopper Oxidase: An Insight Into Water Release Mechanism To be Published
|
|
1H7F
| |
5UJ7
| Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | 著者 | Tocilj, A, Elkayam, E, On, K.F, Joshua-Tor, L. | 登録日 | 2017-01-17 | 公開日 | 2017-02-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.394 Å) | 主引用文献 | Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6, 2017
|
|
6VZ3
| Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | 著者 | Molodtsov, V, Wang, C, Su, M, Ebright, R.H. | 登録日 | 2020-02-27 | 公開日 | 2020-09-02 | 最終更新日 | 2020-09-23 | 実験手法 | ELECTRON MICROSCOPY (8.9 Å) | 主引用文献 | Structural basis of transcription-translation coupling. Science, 369, 2020
|
|
3IWD
| |
1HHS
| RNA dependent RNA polymerase from dsRNA bacteriophage phi6 | 分子名称: | MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. | 登録日 | 2000-12-28 | 公開日 | 2001-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
|
|
1N49
| Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy | 分子名称: | Protease, RITONAVIR | 著者 | Prabu-Jeyabalan, M, Nalivaika, E.A, King, N.M, Schiffer, C.A. | 登録日 | 2002-10-30 | 公開日 | 2003-01-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant:
Structural Insights for Better Antiviral Therapy J.VIROL., 77, 2003
|
|
6VOM
| Chloroplast ATP synthase (R2, CF1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ... | 著者 | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | 登録日 | 2020-01-30 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
|
|
1XV9
| crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione. | 分子名称: | (5BETA)-PREGNANE-3,20-DIONE, Orphan nuclear receptor NR1I3, PENTADECANOIC ACID, ... | 著者 | Xu, R.X, Lambert, M.H, Wisely, B.B, Warren, E.N, Weinert, E.E, Waitt, G.M, Williams, J.D, Moore, L.B, Willson, T.M, Moore, J.T. | 登録日 | 2004-10-27 | 公開日 | 2004-12-28 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer. Mol.Cell, 16, 2004
|
|
4N0T
| Core structure of the U6 small nuclear ribonucleoprotein at 1.7 Angstrom resolution | 分子名称: | SULFATE ION, U4/U6 snRNA-associated-splicing factor PRP24, U6 snRNA | 著者 | Montemayor, E.J, Curran, E.C, Liao, H, Andrews, K.L, Treba, C.N, Butcher, S.E, Brow, D.A. | 登録日 | 2013-10-02 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Core structure of the U6 small nuclear ribonucleoprotein at 1.7- angstrom resolution. Nat.Struct.Mol.Biol., 21, 2014
|
|
1H8D
| X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor. | 分子名称: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, THROMBIN | 著者 | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | 登録日 | 2001-02-01 | 公開日 | 2001-02-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
|
|
5HNO
| The structure of the kdo-capped saccharide binding subunit of the O-12 specific ABC transporter, Wzt | 分子名称: | ABC type transport system putative ATP binding protein, CHLORIDE ION | 著者 | Mallette, E, Mann, E, Whitfield, C, Kimber, M.S. | 登録日 | 2016-01-18 | 公開日 | 2016-03-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Klebsiella pneumoniae O12 ATP-binding Cassette (ABC) Transporter Recognizes the Terminal Residue of Its O-antigen Polysaccharide Substrate. J.Biol.Chem., 291, 2016
|
|
3IWC
| |
3J0S
| Remodeling of actin filaments by ADF cofilin proteins | 分子名称: | Actin, cytoplasmic 1, Cofilin-2 | 著者 | Galkin, V.E, Orlova, A, Kudryashov, D.S, Solodukhin, A, Reisler, E, Schroeder, G.F, Egelman, E.H. | 登録日 | 2011-11-24 | 公開日 | 2011-12-21 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Remodeling of actin filaments by ADF/cofilin proteins. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|