4DGG
c-SRC kinase domain in complex with RM-1-176
Summary for 4DGG
| Entry DOI | 10.2210/pdb4dgg/pdb |
| Related | 3uqf 3uqg |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, 3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
| Functional Keywords | tyrosine protein kinase, atp-binding, kinase domain, transferase |
| Biological source | Gallus gallus (bantam,chickens) |
| Cellular location | Cell membrane (By similarity): P00523 |
| Total number of polymer chains | 2 |
| Total formula weight | 66341.15 |
| Authors | Merritt, E.A.,Larson, E.T. (deposition date: 2012-01-25, release date: 2012-10-10, Last modification date: 2024-02-28) |
| Primary citation | Krishnamurty, R.,Brigham, J.L.,Leonard, S.E.,Ranjitkar, P.,Larson, E.T.,Dale, E.J.,Merritt, E.A.,Maly, D.J. Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol., 9:43-50, 2013 Cited by PubMed: 23143416DOI: 10.1038/nchembio.1118 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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