3UQF

c-SRC kinase domain in complex with BKI RM-1-89

Summary for 3UQF

• Entry DOI: 10.2210/pdb3uqf/pdb
• Related: 3UPX 3UPZ 3UQG 3V51 3V5P 3V5T
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: tyrosine protein kinase, atp-binding, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 66148.12

Authors

Merritt, E.A.,Larson, E.T. (deposition date: 2011-11-20, release date: 2012-03-14, Last modification date: 2024-02-28)

• Primary citation: Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A.; Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.; J.Med.Chem., 55:2803-2810, 2012; PubMed: 22369268; DOI: 10.1021/jm201725v

Experimental method

X-RAY DIFFRACTION (2.27 Å)