3UPX
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
Summary for 3UPX
Entry DOI | 10.2210/pdb3upx/pdb |
Related | 3UPZ 3UQF 3UQG 3V51 3V5P 3V5T |
Descriptor | Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, transferase, calcium-binding, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 55561.33 |
Authors | Merritt, E.A.,Larson, E.T. (deposition date: 2011-11-18, release date: 2012-03-14, Last modification date: 2024-02-28) |
Primary citation | Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A. Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55:2803-2810, 2012 Cited by PubMed: 22369268DOI: 10.1021/jm201725v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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