6MX9
| Lysozyme bound to 3-Aminophenol | 分子名称: | 1,2-ETHANEDIOL, 3-aminophenol, BENZAMIDINE, ... | 著者 | Blackburn, A, Partowmah, S.H, Brennan, H.M, Mestizo, K.E, Stivala, C.D, Petreczky, J, Perez, A, Horn, A, McSweeney, S. | 登録日 | 2018-10-30 | 公開日 | 2018-12-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A simple technique to improve microcrystals using gel exclusion of nucleation inducing elements To Be Published
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7UQB
| Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4 | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-19 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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8EAD
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5N87
| TTK kinase domain in complex with NTRC 0066-0 | 分子名称: | 2,5,8,11-TETRAOXATRIDECANE, Dual specificity protein kinase TTK, SODIUM ION, ... | 著者 | Uitdehaag, J, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-23 | 公開日 | 2017-05-31 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
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6MRJ
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5K9H
| Crystal structure of a glycoside hydrolase 29 family member from an unknown rumen bacterium | 分子名称: | 0940_GH29, GLYCEROL, SODIUM ION, ... | 著者 | Summers, E.L, Arcus, V.L. | 登録日 | 2016-05-31 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.029 Å) | 主引用文献 | The structure of a glycoside hydrolase 29 family member from a rumen bacterium reveals unique, dual carbohydrate-binding domains. Acta Crystallogr.,Sect.F, 72, 2016
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8BV8
| Crystal structure of the phage Mu protein Mom inactive mutant S124A | 分子名称: | Methylcarbamoylase mom | 著者 | Silva, R.M.B, Slyvka, A, Lee, Y.J, Guan, C, Lund, S.R, Raleigh, E.A, Skowronek, K, Bochtler, M, Weigele, P.R. | 登録日 | 2022-12-08 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Crystal structure of the phage Mu protein Mom catalytic mutant S124A To Be Published
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6N2P
| Helical assembly of the CARD9 CARD | 分子名称: | Caspase recruitment domain-containing protein 9 | 著者 | Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J. | 登録日 | 2018-11-13 | 公開日 | 2019-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation. Nat Commun, 10, 2019
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7UOO
| Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-13 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.34 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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7UQZ
| Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-20 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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5NLO
| Auxiliary activity 9 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Auxiliary activity 9, CHLORIDE ION, ... | 著者 | Frandsen, K.E.H, Poulsen, J.-C.N, Tandrup, T, Lo Leggio, L. | 登録日 | 2017-04-04 | 公開日 | 2017-11-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates. Nat Commun, 8, 2017
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5JA5
| Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A and L130A mutant in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-12 | 公開日 | 2017-07-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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7UEP
| PANK3 complex structure with compound PZ-3860 | 分子名称: | 1,2-ETHANEDIOL, 1-[(2R)-4-(6-chloropyridazin-3-yl)-2-methylpiperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M, Lee, R.E. | 登録日 | 2022-03-22 | 公開日 | 2023-03-29 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67, 2024
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6IOK
| Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | 分子名称: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | 著者 | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | 登録日 | 2018-10-30 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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7UEO
| PANK3 complex structure with compound PZ-3977 | 分子名称: | 1,2-ETHANEDIOL, 6-{4-[(4-cyclopropyl-2-fluorophenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M, Lee, R.E. | 登録日 | 2022-03-22 | 公開日 | 2023-03-29 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67, 2024
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5NMR
| Monomeric mouse Sortilin extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Leloup, N.O.L, Loessl, P, Meijer, D.H.M, Heck, A.J.R, Thies-Weesie, D.M.E, Janssen, B.J.C. | 登録日 | 2017-04-07 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8, 2017
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8V81
| Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Gao, X, Hwang, T. | 登録日 | 2023-12-04 | 公開日 | 2024-07-17 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore. Nat Commun, 15, 2024
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8UKD
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6N5J
| FtsY-NG high-resolution | 分子名称: | ACETATE ION, AMMONIUM ION, Signal recognition particle receptor FtsY | 著者 | Ataide, S.F, Faoro, C. | 登録日 | 2018-11-22 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Structural insights into the G-loop dynamics of E. coli FtsY NG domain. J.Struct.Biol., 208, 2019
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7UE5
| PANK3 complex structure with compound PZ-3741 | 分子名称: | 6-[4-({4-[(2R)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, 6-[4-({4-[(2S)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M, Lee, R.E. | 登録日 | 2022-03-21 | 公開日 | 2023-03-29 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67, 2024
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7V08
| Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A suppressor 3 strain | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-05-10 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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8V6R
| Crystal structure of EcThsA in complex with ADPR | 分子名称: | Thoeris protein ThsA Macro domain-containing protein, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | 著者 | Shi, Y, Masic, V, Mosaiab, T, Goulart, C.C, Hartley-Tassell, L, Sorbello, M, Vasquez, E, Mishra, B.P, Holt, S, Gu, W, Kobe, B, Ve, T. | 登録日 | 2023-12-02 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Structural characterization of macro domain-containing Thoeris antiphage defense systems. Sci Adv, 10, 2024
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7UE4
| PANK3 complex structure with compound PZ-3855 | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one, ACETATE ION, ... | 著者 | White, S.W, Yun, M, Lee, R.E. | 登録日 | 2022-03-21 | 公開日 | 2023-03-29 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67, 2024
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7UE3
| PANK3 complex structure with compound PZ-3804 | 分子名称: | 1,2-ETHANEDIOL, 6-[4-({4-[(2R)-1-hydroxypropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M, Lee, R.E. | 登録日 | 2022-03-21 | 公開日 | 2023-03-29 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators. J.Med.Chem., 67, 2024
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5JBG
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