5NMR
Monomeric mouse Sortilin extracellular domain
Summary for 5NMR
| Entry DOI | 10.2210/pdb5nmr/pdb |
| Descriptor | Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | vps10 domain family, sorting receptor, ten-bladed beta propeller, 10cc domain, protein transport |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 82457.19 |
| Authors | Leloup, N.O.L.,Loessl, P.,Meijer, D.H.M.,Heck, A.J.R.,Thies-Weesie, D.M.E.,Janssen, B.J.C. (deposition date: 2017-04-07, release date: 2017-12-06, Last modification date: 2024-01-17) |
| Primary citation | Leloup, N.,Lossl, P.,Meijer, D.H.,Brennich, M.,Heck, A.J.R.,Thies-Weesie, D.M.E.,Janssen, B.J.C. Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8:1708-1708, 2017 Cited by PubMed: 29167428DOI: 10.1038/s41467-017-01485-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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