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5N87

TTK kinase domain in complex with NTRC 0066-0

Summary for 5N87
Entry DOI10.2210/pdb5n87/pdb
Related5N7V
DescriptorDual specificity protein kinase TTK, ~{N}-(2,6-diethylphenyl)-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide, 2,5,8,11-TETRAOXATRIDECANE, ... (5 entities in total)
Functional Keywordskinase, inhibitor, mitosis, mps1, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight36976.18
Authors
Uitdehaag, J.,Willemsen-Seegers, N.,Sterrenburg, J.G.,de Man, J.,Buijsman, R.C.,Zaman, G.J.R. (deposition date: 2017-02-23, release date: 2017-05-31, Last modification date: 2024-01-17)
Primary citationUitdehaag, J.C.M.,de Man, J.,Willemsen-Seegers, N.,Prinsen, M.B.W.,Libouban, M.A.A.,Sterrenburg, J.G.,de Wit, J.J.P.,de Vetter, J.R.F.,de Roos, J.A.D.M.,Buijsman, R.C.,Zaman, G.J.R.
Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429:2211-2230, 2017
Cited by
PubMed: 28539250
DOI: 10.1016/j.jmb.2017.05.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.29 Å)
Structure validation

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