6V6P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v6p by Molmil](/molmil-images/mine/6v6p) | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER, SULFATE ION | 著者 | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | 登録日 | 2019-12-05 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance. J.Biol.Chem., 295, 2020
|
|
7KKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kkj by Molmil](/molmil-images/mine/7kkj) | Structure of anti-SARS-CoV-2 Spike nanobody mNb6 | 分子名称: | CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6 | 著者 | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | 登録日 | 2020-10-27 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370, 2020
|
|
4WRT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wrt by Molmil](/molmil-images/mine/4wrt) | Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | 分子名称: | Influenza virus polymerase vRNA promoter 3' end, Influenza virus polymerase vRNA promoter 5' end, PA, ... | 著者 | Reich, S, Guilligay, D, Pflug, A, Cusack, S. | 登録日 | 2014-10-25 | 公開日 | 2014-11-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
|
|
6LQ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lq0 by Molmil](/molmil-images/mine/6lq0) | |
6EHB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ehb by Molmil](/molmil-images/mine/6ehb) | |
6LKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lkm by Molmil](/molmil-images/mine/6lkm) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide | 分子名称: | 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | 著者 | Miyahara, S, Chong, K.T, Suzuki, T. | 登録日 | 2019-12-19 | 公開日 | 2020-12-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
|
|
8SDI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sdi by Molmil](/molmil-images/mine/8sdi) | |
8SDE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sde by Molmil](/molmil-images/mine/8sde) | |
8FHU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fhu by Molmil](/molmil-images/mine/8fhu) | |
8FFY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ffy by Molmil](/molmil-images/mine/8ffy) | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL) | 分子名称: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ... | 著者 | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | 登録日 | 2022-12-11 | 公開日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition. Nat Commun, 14, 2023
|
|
5L7X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l7x by Molmil](/molmil-images/mine/5l7x) | Afamin antibody fragment, N14 Fab, L1- glycosylated, crystal form II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Mouse Antibody Fab Fragment, ... | 著者 | Rupp, B, Naschberger, A. | 登録日 | 2016-06-04 | 公開日 | 2016-07-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling. Acta Crystallogr D Struct Biol, 72, 2016
|
|
8RXR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rxr by Molmil](/molmil-images/mine/8rxr) | Crystal structure of VPS34 in complex with inhibitor SB02024 | 分子名称: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | 登録日 | 2024-02-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 18, 2024
|
|
7L6M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l6m by Molmil](/molmil-images/mine/7l6m) | |
7KS9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ks9 by Molmil](/molmil-images/mine/7ks9) | |
8HXE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hxe by Molmil](/molmil-images/mine/8hxe) | Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-propylbenzyl)thiazole-4-carboxylic acid | 分子名称: | 2-azanyl-5-[(4-propylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, Metallo-beta-lactamase L1 type 3, THIOCYANATE ION, ... | 著者 | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | 登録日 | 2023-01-04 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.382 Å) | 主引用文献 | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
|
|
7L3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l3n by Molmil](/molmil-images/mine/7l3n) | SARS-CoV 2 Spike Protein bound to LY-CoV555 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV555 Fab heavy chain, ... | 著者 | Goldsmith, J.A, McLellan, J.S. | 登録日 | 2020-12-18 | 公開日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. Biorxiv, 2020
|
|
5KKE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kke by Molmil](/molmil-images/mine/5kke) | |
2RTD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rtd by Molmil](/molmil-images/mine/2rtd) | |
8FF7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ff7 by Molmil](/molmil-images/mine/8ff7) | |
8HXI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hxi by Molmil](/molmil-images/mine/8hxi) | Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-isopropylbenzyl)thiazole-4-carboxylic acid | 分子名称: | 2-azanyl-5-[(4-propan-2-ylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, GLYCEROL, Metallo-beta-lactamase L1 type 3, ... | 著者 | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | 登録日 | 2023-01-04 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
|
|
8FF6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ff6 by Molmil](/molmil-images/mine/8ff6) | |
8FNW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fnw by Molmil](/molmil-images/mine/8fnw) | Structure of RdrA-RdrB complex from Escherichia coli RADAR defense system | 分子名称: | Adenosine deaminase, Archaeal ATPase, ZINC ION | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | 登録日 | 2022-12-28 | 公開日 | 2023-02-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (6.73 Å) | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
8FNT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fnt by Molmil](/molmil-images/mine/8fnt) | Structure of RdrA from Escherichia coli RADAR defense system | 分子名称: | Archaeal ATPase | 著者 | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | 登録日 | 2022-12-28 | 公開日 | 2023-02-01 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
1BGO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bgo by Molmil](/molmil-images/mine/1bgo) | CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR | 分子名称: | 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE, CATHEPSIN K | 著者 | Desjarlais, R.L, Yamashita, D.S, Oh, H.-J, Bondinell, W.E, Uzinskas, I.N, Erhard, K.F, Allen, A.C, Haltiwanger, R.C, Zhao, B, Smith, W.W, Abdel-Meguid, S.S, D'Alessio, K, Janson, C.A, Mcqueney, M.S, Tomaszek, T.A, Levy, M.A, Veber, D.F. | 登録日 | 1998-05-29 | 公開日 | 1999-06-08 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K J.Am.Chem.Soc., 120, 1998
|
|
7ZNJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7znj by Molmil](/molmil-images/mine/7znj) | Structure of an ALYREF-exon junction complex hexamer | 分子名称: | Eukaryotic initiation factor 4A-III, N-terminally processed, MAGNESIUM ION, ... | 著者 | Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. | 登録日 | 2022-04-21 | 公開日 | 2023-04-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023
|
|