PDB: 217686 件ウェブページステータス検索Chemie searchBIRD

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6V6P	Crystal structure of CTX-M-14 E166A/D240G beta-lactamase 分子名称: Beta-lactamase, DI(HYDROXYETHYL)ETHER, SULFATE ION 著者 Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. 登録日 2019-12-05 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance. J.Biol.Chem., 295, 2020
7KKJ	Structure of anti-SARS-CoV-2 Spike nanobody mNb6 分子名称: CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6 著者 Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium 登録日 2020-10-27 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370, 2020
4WRT	Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) 分子名称: Influenza virus polymerase vRNA promoter 3' end, Influenza virus polymerase vRNA promoter 5' end, PA, ... 著者 Reich, S, Guilligay, D, Pflug, A, Cusack, S. 登録日 2014-10-25 公開日 2014-11-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
6LQ0	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C6CoA 分子名称: Acyl-CoA dehydrogenase, COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Liu, X, Chen, X.B. 登録日 2020-01-12 公開日 2020-07-01 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc.Natl.Acad.Sci.USA, 117, 2020
6EHB	OmpU, an outer membrane protein, of Vibrio cholerae 分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Outer membrane protein U 著者 van den berg, B, Pathania, M. 登録日 2017-09-13 公開日 2018-04-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae. Structure, 26, 2018
6LKM	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide 分子名称: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-12-19 公開日 2020-12-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
8SDI	Hydrophobic Interactions Drive the Tetrameric Assembly of the TRIM45 Coiled-Coil Domain 分子名称: Tripartite motif-containing protein 45 著者 Lou, X.H, Ma, B.B, Zhuang, Y, Li, X.C. 登録日 2023-04-06 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Hydrophobic Interactions Drive the Tetrameric Assembly of the TRIM45 Coiled-Coil Domain To Be Published
8SDE	Electrostatic-Mediated Tetramerization of the Coiled-Coil Domain in TRIM29 分子名称: GLYCEROL, Tripartite motif-containing protein 29 著者 Lou, X.H, Zhuang, Y, Ma, B.B, Li, X.C. 登録日 2023-04-06 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Electrostatic-Mediated Tetramerization of the Coiled-Coil Domain in TRIM29 To Be Published
8FHU	Structure of Pyruvate dehydrogenase phosphatase regulatory subunit epitope presented by H2-Dd 分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-D alpha chain, ... 著者 Custodio, J.M.F, Baker, B.M. 登録日 2022-12-15 公開日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structure of Pyruvate dehydrogenase phosphatase regulatory subunit neoepitope presented by H2-Dd To Be Published
8FFY	Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL) 分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ... 著者 Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. 登録日 2022-12-11 公開日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition. Nat Commun, 14, 2023
5L7X	Afamin antibody fragment, N14 Fab, L1- glycosylated, crystal form II 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Mouse Antibody Fab Fragment, ... 著者 Rupp, B, Naschberger, A. 登録日 2016-06-04 公開日 2016-07-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling. Acta Crystallogr D Struct Biol, 72, 2016
8RXR	Crystal structure of VPS34 in complex with inhibitor SB02024 分子名称: 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. 登録日 2024-02-07 公開日 2024-03-20 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 18, 2024
7L6M	Cryo-EM structure of DH898.1 Fab-dimer from local refinement of the Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer 分子名称: DH898.1 Fab heavy chain, DH898.1 Fab light chain 著者 Manne, K, Edwards, R.J, Acharya, P. 登録日 2020-12-23 公開日 2021-02-10 最終更新日 2021-06-09 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021
7KS9	Cryo-EM structure of prefusion SARS-CoV-2 spike glycoprotein in complex with 910-30 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 910-30 Fab heavy chain, ... 著者 Cerutti, G, Shapiro, L. 登録日 2020-11-21 公開日 2021-02-10 最終更新日 2022-11-09 実験手法 ELECTRON MICROSCOPY (4.75 Å) 主引用文献 Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses. Cell Rep, 37, 2021
8HXE	Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-propylbenzyl)thiazole-4-carboxylic acid 分子名称: 2-azanyl-5-[(4-propylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, Metallo-beta-lactamase L1 type 3, THIOCYANATE ION, ... 著者 Yan, Y.-H, Zhu, K.-R, Li, G.-B. 登録日 2023-01-04 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.382 Å) 主引用文献 Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
7L3N	SARS-CoV 2 Spike Protein bound to LY-CoV555 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV555 Fab heavy chain, ... 著者 Goldsmith, J.A, McLellan, J.S. 登録日 2020-12-18 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. Biorxiv, 2020
5KKE	Crystal Structure of a Domain-swapped Dimer of Yeast Iso-1-cytochrome c with CYMAL5 分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, CHLORIDE ION, Cytochrome c iso-1, ... 著者 Bowler, B.E, Whitby, F.G. 登録日 2016-06-21 公開日 2017-03-22 最終更新日 2021-03-10 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons. J. Am. Chem. Soc., 138, 2016
2RTD	STREPTAVIDIN-BIOTIN COMPLEX, PH 1.39, SPACE GROUP I222 分子名称: BIOTIN, STREPTAVIDIN 著者 Katz, B.A. 登録日 1997-09-11 公開日 1998-10-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997
8FF7	Cytosolic ascorbate peroxidase mutant from Panicum virgatum- ascorbate complex 分子名称: ASCORBIC ACID, Cytosolic ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Zhang, B, Kang, C. 登録日 2022-12-07 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.194 Å) 主引用文献 Activity of Cytosolic Ascorbate Peroxidase (APX) from Panicum virgatum against Ascorbate and Phenylpropanoids. Int J Mol Sci, 24, 2023
8HXI	Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-isopropylbenzyl)thiazole-4-carboxylic acid 分子名称: 2-azanyl-5-[(4-propan-2-ylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, GLYCEROL, Metallo-beta-lactamase L1 type 3, ... 著者 Yan, Y.-H, Zhu, K.-R, Li, G.-B. 登録日 2023-01-04 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
8FF6	Cytosolic ascorbate peroxidase mutant from Panicum virgatum 分子名称: Cytosolic ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION 著者 Zhang, B, Kang, C. 登録日 2022-12-07 公開日 2023-02-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Activity of Cytosolic Ascorbate Peroxidase (APX) from Panicum virgatum against Ascorbate and Phenylpropanoids. Int J Mol Sci, 24, 2023
8FNW	Structure of RdrA-RdrB complex from Escherichia coli RADAR defense system 分子名称: Adenosine deaminase, Archaeal ATPase, ZINC ION 著者 Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. 登録日 2022-12-28 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (6.73 Å) 主引用文献 Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
8FNT	Structure of RdrA from Escherichia coli RADAR defense system 分子名称: Archaeal ATPase 著者 Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. 登録日 2022-12-28 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
1BGO	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR 分子名称: 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE, CATHEPSIN K 著者 Desjarlais, R.L, Yamashita, D.S, Oh, H.-J, Bondinell, W.E, Uzinskas, I.N, Erhard, K.F, Allen, A.C, Haltiwanger, R.C, Zhao, B, Smith, W.W, Abdel-Meguid, S.S, D'Alessio, K, Janson, C.A, Mcqueney, M.S, Tomaszek, T.A, Levy, M.A, Veber, D.F. 登録日 1998-05-29 公開日 1999-06-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K J.Am.Chem.Soc., 120, 1998
7ZNJ	Structure of an ALYREF-exon junction complex hexamer 分子名称: Eukaryotic initiation factor 4A-III, N-terminally processed, MAGNESIUM ION, ... 著者 Pacheco-Fiallos, F.B, Vorlaender, M.K, Plaschka, C. 登録日 2022-04-21 公開日 2023-04-12 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 mRNA recognition and packaging by the human transcription-export complex. Nature, 616, 2023

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