7L6M

Cryo-EM structure of DH898.1 Fab-dimer from local refinement of the Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer

Summary for 7L6M

• Entry DOI: 10.2210/pdb7l6m/pdb
• Related: 6XRJ
• EMDB information: 23145
• Descriptor: DH898.1 Fab light chain, DH898.1 Fab heavy chain (2 entities in total)
• Functional Keywords: fab-dimerized, glycan-reactive, antibodies, hiv-1, dh898.1, fab-dimer, glycan-reactive neutralizing antibody, macaque hiv-1 vaccine-induced, b cell lineage, immune system
• Biological source: Macaca mulatta; More
• Total number of polymer chains: 4
• Total formula weight: 94299.69

Authors

Manne, K.,Edwards, R.J.,Acharya, P. (deposition date: 2020-12-23, release date: 2021-02-10, Last modification date: 2021-06-09)

• Primary citation: Williams, W.B.,Meyerhoff, R.R.,Edwards, R.J.,Li, H.,Manne, K.,Nicely, N.I.,Henderson, R.,Zhou, Y.,Janowska, K.,Mansouri, K.,Gobeil, S.,Evangelous, T.,Hora, B.,Berry, M.,Abuahmad, A.Y.,Sprenz, J.,Deyton, M.,Stalls, V.,Kopp, M.,Hsu, A.L.,Borgnia, M.J.,Stewart-Jones, G.B.E.,Lee, M.S.,Bronkema, N.,Moody, M.A.,Wiehe, K.,Bradley, T.,Alam, S.M.,Parks, R.J.,Foulger, A.,Oguin, T.,Sempowski, G.D.,Bonsignori, M.,LaBranche, C.C.,Montefiori, D.C.,Seaman, M.,Santra, S.,Perfect, J.,Francica, J.R.,Lynn, G.M.,Aussedat, B.,Walkowicz, W.E.,Laga, R.,Kelsoe, G.,Saunders, K.O.,Fera, D.,Kwong, P.D.,Seder, R.A.,Bartesaghi, A.,Shaw, G.M.,Acharya, P.,Haynes, B.F.; Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.; Cell, 184:2955-, 2021; PubMed: 34019795; DOI: 10.1016/j.cell.2021.04.042

Experimental method

ELECTRON MICROSCOPY (4.7 Å)