6E0H
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6R7I
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![BU of 6r7i by Molmil](/molmil-images/mine/6r7i) | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | 分子名称: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | 著者 | Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A. | 登録日 | 2019-03-28 | 公開日 | 2019-08-28 | 最終更新日 | 2019-09-04 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun, 10, 2019
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5E6Q
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![BU of 5e6q by Molmil](/molmil-images/mine/5e6q) | Importin alpha binding to XRCC1 NLS peptide | 分子名称: | CHLORIDE ION, DNA repair protein XRCC1 NLS peptide, GLYCEROL, ... | 著者 | Pedersen, L.C, Kirby, T.W, Gassman, N.R, Smith, C.E, Gabel, S.A, Sobhany, M, Wilson, S.H, London, R.E. | 登録日 | 2015-10-10 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.305 Å) | 主引用文献 | Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Sci Rep, 5, 2015
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7Q5A
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![BU of 7q5a by Molmil](/molmil-images/mine/7q5a) | Lanreotide nanotube | 分子名称: | Lanreotide | 著者 | Pieri, L, Wang, F, Arteni, A.A, Bressanelli, S, Egelman, E.H, Paternostre, M. | 登録日 | 2021-11-03 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Atomic structure of Lanreotide nanotubes revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Q1I
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5ZXB
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![BU of 5zxb by Molmil](/molmil-images/mine/5zxb) | Crystal structure of ACK1 with compound 10d | 分子名称: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | 著者 | Hong, E.M, Kim, H.L, Sim, T.B. | 登録日 | 2018-05-18 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
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6DZZ
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![BU of 6dzz by Molmil](/molmil-images/mine/6dzz) | Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation | 分子名称: | (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ... | 著者 | Yang, D, Coleman, J.A, Gouaux, E. | 登録日 | 2018-07-05 | 公開日 | 2019-04-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569, 2019
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7PCQ
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![BU of 7pcq by Molmil](/molmil-images/mine/7pcq) | Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:1 complex | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein B, ... | 著者 | De Bei, O, Gianquinto, E, Chirgadze, D.Y, Hardwick, S.W, Spyrakis, F, Luisi, B.F, Campanini, B. | 登録日 | 2021-08-03 | 公開日 | 2022-04-13 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction. Proc.Natl.Acad.Sci.USA, 119, 2022
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6XL3
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![BU of 6xl3 by Molmil](/molmil-images/mine/6xl3) | Mastigocladopsis repens rhodopsin chloride pump | 分子名称: | CHLORIDE ION, DECANE, Mastigocladopsis repens rhodopsin chloride pump, ... | 著者 | Besaw, J.E, Ernst, O.P, Ou, W, Morizumi, T. | 登録日 | 2020-06-28 | 公開日 | 2020-07-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants. J.Biol.Chem., 295, 2020
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2DPF
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![BU of 2dpf by Molmil](/molmil-images/mine/2dpf) | Crystal Structure of curculin1 homodimer | 分子名称: | Curculin, SULFATE ION | 著者 | Kurimoto, E, Suzuki, M, Amemiya, E, Yamaguchi, Y, Nirasawa, S, Shimba, N, Xu, N, Kashiwagi, T, Kawai, M, Suzuki, E, Kato, K. | 登録日 | 2006-05-11 | 公開日 | 2007-05-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Curculin Exhibits Sweet-tasting and Taste-modifying Activities through Its Distinct Molecular Surfaces. J.Biol.Chem., 282, 2007
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8OOJ
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![BU of 8ooj by Molmil](/molmil-images/mine/8ooj) | Crystal structure of dCK C4S-S74E mutant in complex with EdC and UDP | 分子名称: | 4-azanyl-1-[(2~{R},4~{S},5~{R})-5-ethynyl-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | 著者 | Saez-Ayala, M, Rebuffet, E, Betzi, S, Morelli, X. | 登録日 | 2023-04-05 | 公開日 | 2023-12-20 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Mol.Cancer Ther., 23, 2024
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6XNZ
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![BU of 6xnz by Molmil](/molmil-images/mine/6xnz) | Structure of RAG1 (R848M/E649V)-RAG2-DNA Target Capture Complex | 分子名称: | 12RSS integration strand (34-mer), 12RSS non-integration strand (34-mer), 23RSS integration strand (45-mer), ... | 著者 | Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. | 登録日 | 2020-07-05 | 公開日 | 2020-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
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5DX3
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![BU of 5dx3 by Molmil](/molmil-images/mine/5dx3) | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P3 and Estradiol | 分子名称: | CHLORIDE ION, ESTRADIOL, Estrogen receptor, ... | 著者 | Speltz, T.E, Fanning, S.W, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W. | 登録日 | 2015-09-23 | 公開日 | 2016-07-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.0903 Å) | 主引用文献 | Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew.Chem.Int.Ed.Engl., 55, 2016
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5DXG
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![BU of 5dxg by Molmil](/molmil-images/mine/5dxg) | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P5 | 分子名称: | ESTRADIOL, Estrogen receptor, GLYCEROL, ... | 著者 | Fanning, S.W, Speltz, T.E, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W. | 登録日 | 2015-09-23 | 公開日 | 2016-07-27 | 最終更新日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew. Chem. Int. Ed. Engl., 55, 2016
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5DZ2
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![BU of 5dz2 by Molmil](/molmil-images/mine/5dz2) | Geosmin synthase from Streptomyces coelicolor N-terminal domain complexed with three Mg2+ ions and alendronic acid | 分子名称: | ALENDRONATE, Germacradienol/geosmin synthase, MAGNESIUM ION | 著者 | Harris, G.G, Lombardi, P.M, Pemberton, T.A, Matsui, T, Weiss, T.M, Cole, K.E, Koksal, M, Murphy, F.V, Vedula, L.S, Chou, W.K.W, Cane, D.E, Christianson, D.W. | 登録日 | 2015-09-25 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.111 Å) | 主引用文献 | Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with alpha alpha Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry, 54, 2015
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1SLS
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![BU of 1sls by Molmil](/molmil-images/mine/1sls) | IMMOBILE SLIPPED-LOOP STRUCTURE (SLS) OF DNA HOMODIMER IN SOLUTION, NMR, 9 STRUCTURES | 分子名称: | OLIGODEOXYRIBONUCLEOTIDE | 著者 | Ulyanov, N.B, Ivanov, V.I, Minyat, E.E, Khomyakova, E.B, Petrova, M.V, Lesiak, K, James, T.L. | 登録日 | 1997-09-30 | 公開日 | 1998-04-08 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A pseudosquare knot structure of DNA in solution. Biochemistry, 37, 1998
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7Q32
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![BU of 7q32 by Molmil](/molmil-images/mine/7q32) | Mutant D24G of uridine phosphorylase from E. coli | 分子名称: | CITRATE ANION, POTASSIUM ION, Uridine phosphorylase | 著者 | Safonova, T, Polyakov, K, Antipov, A, Okorokova, N, Mordkovich, N, Veiko, V. | 登録日 | 2021-10-26 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mutant D24G of uridine phosphorylase from E. coli To Be Published
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8OOI
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![BU of 8ooi by Molmil](/molmil-images/mine/8ooi) | Full composite cryo-EM map of p97/VCP in ADP.Pi state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Cheng, T.C, Sakata, E, Schuetz, A.K. | 登録日 | 2023-04-05 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Characterizing ATP processing by the AAA+ protein p97 at the atomic level. Nat.Chem., 16, 2024
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3IAR
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![BU of 3iar by Molmil](/molmil-images/mine/3iar) | The crystal structure of human adenosine deaminase | 分子名称: | (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Adenosine deaminase, GLYCEROL, ... | 著者 | Ugochukwu, E, Zhang, Y, Hapka, E, Yue, W.W, Bray, J.E, Muniz, J, Burgess-Brown, N, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2009-07-14 | 公開日 | 2009-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | The crystal structure of human adenosine deaminase To be Published
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4KYN
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8OUE
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![BU of 8oue by Molmil](/molmil-images/mine/8oue) | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | 登録日 | 2023-04-22 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein. Nat Commun, 15, 2024
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8OUF
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![BU of 8ouf by Molmil](/molmil-images/mine/8ouf) | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | 登録日 | 2023-04-22 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein. Nat Commun, 15, 2024
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6RQF
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![BU of 6rqf by Molmil](/molmil-images/mine/6rqf) | 3.6 Angstrom cryo-EM structure of the dimeric cytochrome b6f complex from Spinacia oleracea with natively bound thylakoid lipids and plastoquinone molecules | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | 著者 | Malone, L.A, Qian, P, Mayneord, G.E, Hitchcock, A, Farmer, D, Thompson, R, Swainsbury, D.J.K, Ranson, N, Hunter, C.N, Johnson, M.P. | 登録日 | 2019-05-15 | 公開日 | 2019-11-13 | 最終更新日 | 2019-12-04 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Cryo-EM structure of the spinach cytochrome b6f complex at 3.6 angstrom resolution. Nature, 575, 2019
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1F07
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![BU of 1f07 by Molmil](/molmil-images/mine/1f07) | STRUCTURE OF COENZYME F420 DEPENDENT TETRAHYDROMETHANOPTERIN REDUCTASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | 著者 | Shima, S, Warkentin, E, Grabarse, W, Thauer, R.K, Ermler, U. | 登録日 | 2000-05-15 | 公開日 | 2000-09-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of coenzyme F(420) dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea. J.Mol.Biol., 300, 2000
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5AQN
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![BU of 5aqn by Molmil](/molmil-images/mine/5aqn) | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, BENZOFURO[3,2-D]PYRIMIDIN-4(3H)-ONE, ... | 著者 | Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. | 登録日 | 2015-09-22 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
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