5DZ2

Geosmin synthase from Streptomyces coelicolor N-terminal domain complexed with three Mg2+ ions and alendronic acid

Summary for 5DZ2

• Entry DOI: 10.2210/pdb5dz2/pdb
• Related: 5DW7
• Descriptor: Germacradienol/geosmin synthase, MAGNESIUM ION, ALENDRONATE, ... (4 entities in total)
• Functional Keywords: terpene, cyclase, geosmin, germacradienol, lyase
• Biological source: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
• Total number of polymer chains: 2
• Total formula weight: 77177.80

Authors

Harris, G.G.,Lombardi, P.M.,Pemberton, T.A.,Matsui, T.,Weiss, T.M.,Cole, K.E.,Koksal, M.,Murphy, F.V.,Vedula, L.S.,Chou, W.K.W.,Cane, D.E.,Christianson, D.W. (deposition date: 2015-09-25, release date: 2015-12-09, Last modification date: 2023-09-27)

• Primary citation: Harris, G.G.,Lombardi, P.M.,Pemberton, T.A.,Matsui, T.,Weiss, T.M.,Cole, K.E.,Koksal, M.,Murphy, F.V.,Vedula, L.S.,Chou, W.K.,Cane, D.E.,Christianson, D.W.; Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with alpha alpha Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.; Biochemistry, 54:7142-7155, 2015; PubMed: 26598179; DOI: 10.1021/acs.biochem.5b01143

Experimental method

X-RAY DIFFRACTION (2.111 Å)