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8TYO
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Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Bruch, E.M, Rak, A.
登録日2023-08-25
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2.
Sci Rep, 14, 2024
8TYL
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Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Bruch, E.M, Rak, A.
登録日2023-08-25
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2.
Sci Rep, 14, 2024
5WCM
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BU of 5wcm by Molmil
Crystal structure of the complex between class B3 beta-lactamase BJP-1 and 4-nitrobenzene-sulfonamide - new refinement
分子名称: 4-nitrobenzenesulfonamide, Blr6230 protein, ZINC ION
著者Docquier, J.D, Benvenuti, M, Calderone, V, Menciassi, N, Shabalin, I.G, Raczynska, J.E, Wlodawer, A, Jaskolski, M, Minor, W, Mangani, S.
登録日2017-06-30
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献High-resolution crystal structure of the subclass B3 metallo-beta-lactamase BJP-1: rational basis for substrate specificity and interaction with sulfonamides.
Antimicrob. Agents Chemother., 54, 2010
8S9V
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BU of 8s9v by Molmil
CRISPR-Cas type III-D effector complex bound to a self-target RNA in the pre-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
4UI0
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BU of 4ui0 by Molmil
Crystal structure of the human RGMB-BMP2 complex, crystal form 2
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ...
著者Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C.
登録日2015-03-27
公開日2015-05-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
8S9X
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CRISPR-Cas type III-D effector complex bound to self-target RNA in a post-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8SKT
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BU of 8skt by Molmil
Structure of ternary complex of mouse cGAS with dsDNA and bound ATP with 5 mM Mn2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MANGANESE (II) ION, ...
著者Wu, S, Sohn, J.
登録日2023-04-20
公開日2024-04-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
Nat Commun, 15, 2024
4UPJ
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HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 PROTEASE MUTANT WITH LYS 57 REPLACED BY LEU (K57L) COMPLEX WITH U097410 [4-HYDROXY-3-[1-[3-[[[[(TERT-BUTYLOXYCARBONYL) AMINOMETHYL]CARBONYL]AMINO]PHENYL]PROPYL]COUMARIN
分子名称: ({3-[1-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-PROPYL]-PHENYLCARBAMOYL}-METHYL)-CARBAMIC ACID TERT-BUTYL ESTER, HIV-2 PROTEASE
著者Watenpaugh, K.D, Mulichak, A.M, Janakiraman, M.N.
登録日1996-03-04
公開日1996-10-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.
J.Med.Chem., 38, 1995
8S9T
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CRISPR-Cas type III-D effector complex
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.52 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8U0P
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Synaptic complex of human DNA polymerase Lambda DL variant engaged on a noncomplementary DNA double-strand break
分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
著者Kaminski, A.M, Pedersen, L.C, Bebenek, K, Kunkel, T.A, Chiruvella, K.K, Ramsden, D.A.
登録日2023-08-29
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
DNA Repair (Amst), 136, 2024
4UMV
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CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN THE E2P STATE
分子名称: BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ZINC-TRANSPORTING ATPASE
著者Wang, K.T, Sitsel, O, Meloni, G, Autzen, H.E, Andersson, M, Klymchuk, T, Nielsen, A.M, Rees, D.C, Nissen, P, Gourdon, P.
登録日2014-05-21
公開日2014-08-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases.
Nature, 514, 2014
4UEA
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Complex of D. melanogaster eIF4E with a designed 4E-binding protein (Form I)
分子名称: DESIGNED 4E-BP, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
著者Peter, D, Weichenrieder, O.
登録日2014-12-16
公開日2015-02-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E.
Mol.Cell, 57, 2015
4UC7
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N-terminal globular domain of the RSV Nucleoprotein
分子名称: NUCLEOPROTEIN, SULFATE ION
著者Ouizougun-Oubari, M, Pereira, N, Tarus, B, Galloux, M, Tortorici, M.-A, Hoos, S, Baron, B, England, P, Bontems, F, Rey, F.A, Eleouet, J.-F, Sizun, C, Slama-Schwok, A, Duquerroy, S.
登録日2014-12-03
公開日2015-08-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of the Human Respiratory Syncytial Virus.
J.Virol., 89, 2015
8S4S
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BU of 8s4s by Molmil
PrgE from plasmid pCF10
分子名称: POTASSIUM ION, PrgE, SULFATE ION
著者Breidenstein, A, Berntsson, R.P.-A.
登録日2024-02-22
公開日2024-05-29
最終更新日2024-07-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs.
Life Sci Alliance, 7, 2024
4D89
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BU of 4d89 by Molmil
Crystal Structure of Human Beta Secretase in Complex with NVP-BXD552, derived from a soaking experiment
分子名称: (3S,4S,5R)-3-(4-amino-3-{[(2R)-3-ethoxy-1,1,1-trifluoropropan-2-yl]oxy}-5-fluorobenzyl)-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1
著者Rondeau, J.M, Bourgier, E.
登録日2012-01-10
公開日2012-11-21
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides
J.Med.Chem., 55, 2012
4UMW
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CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN E2.PI STATE
分子名称: MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ZINC-TRANSPORTING ATPASE
著者Wang, K.T, Sitsel, O, Meloni, G, Autzen, H.E, Andersson, M, Klymchuk, T, Nielsen, A.M, Rees, D.C, Nissen, P, Gourdon, P.
登録日2014-05-21
公開日2014-08-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases.
Nature, 514, 2014
4V5Z
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BU of 4v5z by Molmil
Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map
分子名称: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S Ribosomal protein RACK1, ...
著者Chandramouli, P, Akey, C.W.
登録日2008-03-27
公開日2014-07-09
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (8.7 Å)
主引用文献Structure of the Mammalian 80S Ribosome at 8.7 A Resolution
Structure, 16, 2008
8T5L
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BU of 8t5l by Molmil
Crystal structure of STING CTD in complex with 2'3'-cGAMP
分子名称: Stimulator of interferon genes protein, cGAMP
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
8T5K
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BU of 8t5k by Molmil
Crystal structure of STING CTD in complex with BDW-OH
分子名称: Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
2TSC
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BU of 2tsc by Molmil
STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE
分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Montfort, W.R, Stroud, R.M.
登録日1991-07-03
公開日1991-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry, 29, 1990
7KZX
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Cryo-EM structure of YiiP-Fab complex in Apo state
分子名称: Cadmium and zinc efflux pump FieF, Fab2R heavy chain, Fab2R light chain
著者Lopez-Redondo, M.L, Fan, S, Koide, A, Koide, S, Beckstein, O, Stokes, D.L.
登録日2020-12-10
公開日2021-01-06
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP.
J.Gen.Physiol., 153, 2021
7KZZ
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Cryo-EM structure of YiiP-Fab complex in Holo state
分子名称: Cadmium and zinc efflux pump FieF, Fab2R heavy chain, Fab2R light chain, ...
著者Lopez-Redondo, M.L, Fan, S, Koide, A, Koide, S, Beckstein, O, Stokes, D.L.
登録日2020-12-10
公開日2021-01-06
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP.
J.Gen.Physiol., 153, 2021
4V99
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The Crystallographic Structure of Panicum Mosaic Virus
分子名称: 5'-R(P*UP*UP*AP*AP*UP*AP*UP*UP*UP*UP*UP*AP*UP*UP*UP*UP*U)-3', CALCIUM ION, Capsid protein
著者Makino, D.L, Larson, S.B, McPherson, A.
登録日2012-07-04
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystallographic structure of Panicum Mosaic Virus (PMV).
J.Struct.Biol., 181, 2013
4W5R
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The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-08-18
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
4W5Q
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The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8
分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-08-18
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014

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