8U0P
Synaptic complex of human DNA polymerase Lambda DL variant engaged on a noncomplementary DNA double-strand break
Summary for 8U0P
Entry DOI | 10.2210/pdb8u0p/pdb |
Descriptor | DNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ... (10 entities in total) |
Functional Keywords | nonhomologous end-joining, base excision repair, dna polymerase, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 44930.12 |
Authors | Kaminski, A.M.,Pedersen, L.C.,Bebenek, K.,Kunkel, T.A.,Chiruvella, K.K.,Ramsden, D.A. (deposition date: 2023-08-29, release date: 2024-03-13) |
Primary citation | Kaminski, A.M.,Chiruvella, K.K.,Ramsden, D.A.,Bebenek, K.,Kunkel, T.A.,Pedersen, L.C. DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining. DNA Repair (Amst), 136:103645-103645, 2024 Cited by PubMed: 38428373DOI: 10.1016/j.dnarep.2024.103645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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