PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

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7DTE	SARS-CoV-2 RdRP catalytic complex with T33-1 RNA 分子名称: Non-structural protein 7, Non-structural protein 8, RNA (33-MER), ... 著者 Wang, Q, Gong, P. 登録日 2021-01-04 公開日 2021-10-20 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Rep, 37, 2021
7LW6	The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with Raltegravir 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, ... 著者 Cuypers, M.G, Slavish, P.J, White, S.W, Rankovik, Z. 登録日 2021-02-27 公開日 2021-05-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7EJU	Junin virus(JUNV) RNA polymerase L complexed with Z protein 分子名称: MAGNESIUM ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Chen, Y. 登録日 2021-04-02 公開日 2021-07-07 最終更新日 2022-01-19 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis for recognition and regulation of arenavirus polymerase L by Z protein. Nat Commun, 12, 2021
1RA7	Poliovirus Polymerase with GTP 分子名称: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
1RAJ	Poliovirus Polymerase with a 68 residue N-terminal truncation 分子名称: Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
1RA6	Poliovirus Polymerase Full Length Apo Structure 分子名称: ACETIC ACID, Genome polyprotein 著者 Thompson, A.A, Peersen, O.B. 登録日 2003-10-31 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase. Embo J., 23, 2004
1KKS	Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression 分子名称: 5'-R(*GP*GP*AP*AP*GP*GP*CP*CP*CP*UP*UP*UP*UP*CP*AP*GP*GP*GP*CP*CP*AP*CP*CP*C)-3' 著者 Zanier, K, Luyten, I, Crombie, C, Muller, B, Schuemperli, D, Linge, J.P, Nilges, M, Sattler, M. 登録日 2001-12-10 公開日 2002-03-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression. RNA, 8, 2002
6V6X	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000988632 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, N-[2-(6-amino-9H-purin-9-yl)ethyl]-5-hydroxy-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2019-12-06 公開日 2020-12-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VG9	The crystal structure of the 2009 H1N1/California PA endonuclease I38T mutant in complex with SJ000986248 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-01-07 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6V9E	The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000988632 分子名称: 1,1',1'',1''',1''''-[(3R,5S,7S,9R)-decane-1,3,5,7,9-pentayl]penta(pyrrolidin-2-one), MANGANESE (II) ION, N-[2-(6-amino-9H-purin-9-yl)ethyl]-5-hydroxy-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2019-12-13 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VBR	The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986248 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2019-12-19 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VL3	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986436 分子名称: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. 登録日 2020-01-22 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VJH	The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with SJ000986192 分子名称: 2-[2-[(cyclohexylmethyl-$l^{3}-oxidanyl)carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-01-16 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6VIV	The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986192 分子名称: 2-[2-[(cyclohexylmethyl-$l^{3}-oxidanyl)carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-01-14 公開日 2021-02-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7RIL	Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG 分子名称: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, ACETATE ION, non-template DNA, ... 著者 Oh, J, Dervan, P.B, Wang, D. 登録日 2021-07-20 公開日 2022-01-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc.Natl.Acad.Sci.USA, 119, 2022
6WIJ	The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986448 分子名称: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-04-10 公開日 2021-04-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6WJ4	The crystal structure of the 2009/H1N1/California PA endonuclease wild type in complex with SJ000986448 分子名称: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. 登録日 2020-04-11 公開日 2021-04-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
2GIR	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor 分子名称: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
1YTY	Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen 分子名称: 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein 著者 Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J. 登録日 2005-02-11 公開日 2006-01-17 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen. Mol.Cell, 21, 2006
1ZH5	Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen 分子名称: 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein, SULFATE ION 著者 Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J. 登録日 2005-04-22 公開日 2006-01-17 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen. Mol.Cell, 21, 2006
2GIQ	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor 分子名称: 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
3FQL	Hepatitis C virus polymerase NS5B (CON1 1-570) with HCV-796 inhibitor 分子名称: 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, RNA-directed RNA polymerase 著者 Harris, S.F, Wong, A. 登録日 2009-01-07 公開日 2009-02-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J.Biol.Chem., 284, 2009
3FQK	Hepatitis C virus polymerase NS5B (BK 1-570) with HCV-796 inhibitor 分子名称: 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase 著者 Harris, S.F, Wong, A. 登録日 2009-01-07 公開日 2009-02-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J.Biol.Chem., 284, 2009
2GC8	Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase 分子名称: 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE, RNA-directed RNA polymerase 著者 Gopalsamy, A, Chopra, R, Lim, K, Ciszewski, G, Shi, M, Curran, K.J, Sukits, S.F, Svenson, K, Bard, J, Ellingboe, J.W, Agarwal, A, Krishnamurthy, G, Howe, A.Y, Orlowski, M, Feld, B, O'connell, J, Mansour, T.S. 登録日 2006-03-13 公開日 2006-06-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site. J.Med.Chem., 49, 2006
3E51	Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-pyrrolidin-1-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents. Bioorg.Med.Chem.Lett., 18, 2008

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