3FQL

Hepatitis C virus polymerase NS5B (CON1 1-570) with HCV-796 inhibitor

Summary for 3FQL

• Entry DOI: 10.2210/pdb3fql/pdb
• Related: 2GIQ 2GIR 3FQK
• Descriptor: RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hcv, hepatitis, ns5b, transferase, rna-dependent rna polymerase, hcv-796
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q9WMX2
• Total number of polymer chains: 1
• Total formula weight: 65020.63

Authors

Harris, S.F.,Wong, A. (deposition date: 2009-01-07, release date: 2009-02-24, Last modification date: 2023-09-06)

• Primary citation: Hang, J.Q.,Yang, Y.,Harris, S.F.,Leveque, V.,Whittington, H.J.,Rajyaguru, S.,Ao-Ieong, G.,McCown, M.F.,Wong, A.,Giannetti, A.M.,Le Pogam, S.,Talamas, F.,Cammack, N.,Najera, I.,Klumpp, K.; Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.; J.Biol.Chem., 284:15517-15529, 2009; PubMed: 19246450; DOI: 10.1074/jbc.M808889200

Experimental method

X-RAY DIFFRACTION (1.8 Å)