3FQK
Hepatitis C virus polymerase NS5B (BK 1-570) with HCV-796 inhibitor
Summary for 3FQK
Entry DOI | 10.2210/pdb3fqk/pdb |
Related | 2GIQ 2GIR 3FQL |
Descriptor | RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide (3 entities in total) |
Functional Keywords | hcv, hepatitis, ns5b, transferase, rna-dependent rna polymerase, hcv-796 |
Biological source | Hepatitis C virus (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
Total number of polymer chains | 2 |
Total formula weight | 129246.29 |
Authors | Harris, S.F.,Wong, A. (deposition date: 2009-01-07, release date: 2009-02-24, Last modification date: 2024-10-16) |
Primary citation | Hang, J.Q.,Yang, Y.,Harris, S.F.,Leveque, V.,Whittington, H.J.,Rajyaguru, S.,Ao-Ieong, G.,McCown, M.F.,Wong, A.,Giannetti, A.M.,Le Pogam, S.,Talamas, F.,Cammack, N.,Najera, I.,Klumpp, K. Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J.Biol.Chem., 284:15517-15529, 2009 Cited by PubMed: 19246450DOI: 10.1074/jbc.M808889200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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