2GIQ
Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor
Summary for 2GIQ
Entry DOI | 10.2210/pdb2giq/pdb |
Descriptor | RNA-directed RNA polymerase, 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE (3 entities in total) |
Functional Keywords | hcv, hepatitis, ns5b, transferase, rna-dependent rna polymerase |
Biological source | Hepatitis C virus (isolate BK) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663 |
Total number of polymer chains | 2 |
Total formula weight | 127354.01 |
Authors | Harris, S.F. (deposition date: 2006-03-29, release date: 2007-04-03, Last modification date: 2024-02-14) |
Primary citation | Le Pogam, S.,Kang, H.,Harris, S.F.,Leveque, V.,Giannetti, A.M.,Ali, S.,Jiang, W.R.,Rajyaguru, S.,Tavares, G.,Oshiro, C.,Hendricks, T.,Klumpp, K.,Symons, J.,Browner, M.F.,Cammack, N.,Najera, I. Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80:6146-6154, 2006 Cited by PubMed: 16731953DOI: 10.1128/JVI.02628-05 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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