2GIQ

Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA-directed RNA polymerase	polymer	568	63249.6	2	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus (isolate BK)	NS5B, p68
2	A, B	1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE	non-polymer		427.4	2	Chemie (NN2)
3		water	water		18.0	518	Chemie (HOH)

Sequence modifications

A, B: 2 - 562 (UniProt: P26663)

PDB	External Database	Details
Met -5	-	cloning artifact
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	126499.1
Non-Polymers*	Number of molecules	2
	Total formula weight	854.9
All*	Total formula weight	127354.0

*Water molecules are not included.