7LW6

The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with Raltegravir

Summary for 7LW6

Entry DOI	10.2210/pdb7lw6/pdb
Descriptor	Polymerase acidic protein, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, ... (6 entities in total)
Functional Keywords	nuclease, influenza, inhibitor resistance, viral protein, hydrolase
Biological source	Influenza A virus (A/Luxembourg/43/2009(H1N1)) More
Total number of polymer chains	1
Total formula weight	24455.51
Authors	Cuypers, M.G.,Slavish, P.J.,White, S.W.,Rankovik, Z. (deposition date: 2021-02-27, release date: 2021-05-26, Last modification date: 2023-10-25)
Primary citation	Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W. Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247:115035-115035, 2023 Cited by PubMed: 36603507 DOI: 10.1016/j.ejmech.2022.115035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.38 Å)

Structure validation