5ZC9
| Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex | 分子名称: | (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... | 著者 | Iwasaki, W, Takahashi, M, Sakamoto, A, Iwasaki, S, Ito, T. | 登録日 | 2018-02-16 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. Mol. Cell, 73, 2019
|
|
7Y61
| Cryo-EM structure of the two CAF1LCs bound right-handed Di-tetrasome | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | 著者 | Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M. | 登録日 | 2022-06-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
|
|
7Y60
| Cryo-EM structure of human CAF1LC bound right-handed Di-tetrasome | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | 著者 | Liu, C.P, Yu, C, Yu, Z.Y, Xu, R.M. | 登録日 | 2022-06-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
|
|
7Y5W
| Cryo-EM structure of the left-handed Di-tetrasome | 分子名称: | Histone H3.1, Histone H4, Widom 601 DNA (147-MER) | 著者 | Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M. | 登録日 | 2022-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
|
|
5X0I
| |
5XF4
| Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (S,S-configuration) | 分子名称: | (1S,2S)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | 著者 | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | 登録日 | 2017-04-07 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8, 2017
|
|
5X7X
| The crystal structure of the nucleosome containing H3.3 at 2.18 angstrom resolution | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | 著者 | Arimura, Y, Taguchi, H, Kurumizaka, H. | 登録日 | 2017-02-27 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.184 Å) | 主引用文献 | Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
|
|
7VZ4
| Cryo-EM structure of human nucleosome core particle composed of the Widom 601L DNA sequence | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Takizawa, Y, Ho, C.-H, Sato, S, Danev, R, Kurumizaka, H. | 登録日 | 2021-11-15 | 公開日 | 2023-05-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (1.89 Å) | 主引用文献 | Methods for High Resolution Cryo-EM Analyses of Nucleosomes To Be Published
|
|
7W1M
| Cryo-EM structure of human cohesin-CTCF-DNA complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... | 著者 | Shi, Z.B, Bai, X.C, Yu, H. | 登録日 | 2021-11-19 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
|
|
7Z4Z
| Human NEXT dimer - focused reconstruction of the dimerization module | 分子名称: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | 著者 | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | 登録日 | 2022-03-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
|
|
5VMY
| Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a hemi CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*CP*GP*CP*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | 著者 | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | 登録日 | 2017-04-28 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
|
|
7Z4Y
| Human NEXT dimer - overall reconstruction of the core complex | 分子名称: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | 著者 | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | 登録日 | 2022-03-06 | 公開日 | 2022-06-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
|
|
5VMW
| Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a double CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*(5CM)P*GP*(5CM)P*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | 著者 | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | 登録日 | 2017-04-28 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
|
|
5ZAD
| Human topoisomerase II beta in complex with DNA | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta | 著者 | Sun, L.Y, Zhu, L.W, Tang, Y.J. | 登録日 | 2018-02-07 | 公開日 | 2019-03-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. Sci Rep, 8, 2018
|
|
5ZBX
| The crystal structure of the nucleosome containing histone H3.1 CATD(V76Q, K77D) | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | 著者 | Arimura, Y, Takagi, H, Kurumizaka, H. | 登録日 | 2018-02-13 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism. Nat Commun, 10, 2019
|
|
5ZEN
| Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Chen, S.F, Wang, Y.R, Chan, N.L. | 登録日 | 2018-02-27 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
|
|
7XZX
| Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain | 分子名称: | Cellular tumor antigen p53, DNA (193-MER), Histone H2A type 1-B/E, ... | 著者 | Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H. | 登録日 | 2022-06-03 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.53 Å) | 主引用文献 | Structural basis for p53 binding to its nucleosomal target DNA sequence. Pnas Nexus, 1, 2022
|
|
7Y8R
| The nucleosome-bound human PBAF complex | 分子名称: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | 著者 | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | 登録日 | 2022-06-24 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
|
|
5Z56
| cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | 登録日 | 2018-01-17 | 公開日 | 2018-09-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
|
|
5ZQF
| Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221 | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... | 著者 | Chen, S.F, Wang, Y.R, Chan, N.L. | 登録日 | 2018-04-18 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.873 Å) | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
|
|
7ZBG
| Human Topoisomerase II Beta ATPase ADP | 分子名称: | 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione, ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, ... | 著者 | Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A. | 登録日 | 2022-03-23 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure, 30, 2022
|
|
5Y0C
| Crystal Structure of the human nucleosome at 2.09 angstrom resolution | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | 著者 | Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. | 登録日 | 2017-07-16 | 公開日 | 2018-07-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.087 Å) | 主引用文献 | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
|
|
7YOZ
| Cryo-EM structure of human subnucleosome (intermediate form) | 分子名称: | Histone H3.1, Histone H4, Widom601 DNA FW (145-MER), ... | 著者 | Nozawa, K, Takizawa, Y, Kurumizaka, H. | 登録日 | 2022-08-02 | 公開日 | 2022-11-16 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-electron microscopy structure of the H3-H4 octasome: A nucleosome-like particle without histones H2A and H2B. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7YQK
| cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1 | 分子名称: | DNA (145-MER), Histone H2AX, Histone H2B, ... | 著者 | Ai, H.S, GuoChao, C, Qingyue, G, Ze-Bin, T, Zhiheng, D, Xin, L, Fan, Y, Ziyu, X, Jia-Bin, L, Changlin, T, Liu, L. | 登録日 | 2022-08-07 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes. J.Am.Chem.Soc., 144, 2022
|
|
5XF3
| Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,R-configuration) | 分子名称: | (1R,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ... | 著者 | Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A. | 登録日 | 2017-04-07 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation Nat Commun, 8, 2017
|
|