5ZC9

Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex

Summary for 5ZC9

• Entry DOI: 10.2210/pdb5zc9/pdb
• Descriptor: Eukaryotic initiation factor 4A-I, RNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3'), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• Functional Keywords: initiation factor, dead-box, helicase, protein-rna complex, atpase, rocaglamide a, anticancer compound, translation, translation-rna complex, translation/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 49264.61

Authors

Iwasaki, W.,Takahashi, M.,Sakamoto, A.,Iwasaki, S.,Ito, T. (deposition date: 2018-02-16, release date: 2019-01-16, Last modification date: 2023-11-22)

• Primary citation: Iwasaki, S.,Iwasaki, W.,Takahashi, M.,Sakamoto, A.,Watanabe, C.,Shichino, Y.,Floor, S.N.,Fujiwara, K.,Mito, M.,Dodo, K.,Sodeoka, M.,Imataka, H.,Honma, T.,Fukuzawa, K.,Ito, T.,Ingolia, N.T.; The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.; Mol. Cell, 73:738-, 2019; PubMed: 30595437; DOI: 10.1016/j.molcel.2018.11.026

Experimental method

X-RAY DIFFRACTION (2 Å)