5ZC9
Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic initiation factor 4A-I | polymer | 394 | 44901.4 | 1 | UniProt (P60842) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (Human) | Eukaryotic translation initiation factor 4A-I,eIF4A-I,ATP-dependent RNA helicase eIF4A-1 |
| 2 | B (B) | RNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3') | polymer | 10 | 3327.1 | 1 | synthetic construct | ||
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (B) | (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide | non-polymer | 505.6 | 1 | Chemie (RCG) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 19 - 406 (UniProt: P60842)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Tyr 16 | - | expression tag |
| Gln 17 | - | expression tag |
| Asp 18 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48228.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1036.1 | |
| All* | Total formula weight | 49264.6 |
