5ZC9

Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
AEukaryotic initiation factor 4A-Ipolymer39444901.41
UniProt (P60842)
Pfam (PF00270)
Pfam (PF00271)
Homo sapiens (Human)Eukaryotic translation initiation factor 4A-I,eIF4A-I,ATP-dependent RNA helicase eIF4A-1
BRNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3')polymer103327.11
synthetic construct
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21
MAGNESIUM IONnon-polymer24.31
(1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamidenon-polymer505.61
waterwater18.0246

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains2
Total molecular weight48228.5
Non-Polymers*Number of molecules3
Total molecular weight1036.1
All*Total molecular weight49264.6
*Water molecules are not included.