PDB: 1628 件ウェブページステータス検索Chemie searchBIRD

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8HVI	Activation mechanism of GPR132 by compound NOX-6-7 分子名称: 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8WW2	GPR3/Gs complex 分子名称: CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Xiong, Y. 登録日 2023-10-24 公開日 2024-02-14 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
8HJ2	GPR21 wt with G15 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HJ0	GPR21(m5) and G15 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X. 登録日 2022-11-22 公開日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HIX	Cryo-EM structure of GPR21_m5_Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-03-15 最終更新日 2023-03-22 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HJ1	GPR21(wt) and Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
5TSF	Crystal structure of AChBP from Aplysia californica complex with 2-aminopyrimidine at pH 7.0 spacegroup P212121 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-chloro-N~4~,N~4~-bis[(pyridin-3-yl)methyl]pyrimidine-2,4-diamine, Soluble acetylcholine receptor 著者 Camacho-Hernandez, G.A, Kaczanowska, K, Harel, M, Finn, M.G, Taylor, P.W. 登録日 2016-10-28 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.286 Å) 主引用文献 Crystal structure of AChBP from Aplysia californica complex with 2-aminopyrimidine at pH 7.0 spacegroup P212121 To Be Published
8EAQ	Structure of the full-length IP3R1 channel determined at high Ca2+ 分子名称: (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, CALCIUM ION, Inositol 1,4,5-trisphosphate receptor type 1, ... 著者 Fan, G, Baker, M.R, Terry, L.E, Arige, V, Chen, M, Seryshev, A.B, Baker, M.L, Ludtke, S.J, Yule, D.I, Serysheva, I.I. 登録日 2022-08-29 公開日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Conformational motions and ligand-binding underlying gating and regulation in IP 3 R channel. Nat Commun, 13, 2022
8EAR	Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP 分子名称: (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... 著者 Fan, G, Baker, M.R, Terry, L.E, Arige, V, Chen, M, Seryshev, A.B, Baker, M.L, Ludtke, S.J, Yule, D.I, Serysheva, I.I. 登録日 2022-08-29 公開日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Conformational motions and ligand-binding underlying gating and regulation in IP 3 R channel. Nat Commun, 13, 2022
8G2Y	Cryo-EM structure of ADGRF1 coupled to miniGs/q 分子名称: Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jones, D, Rawson, S, Blacklow, S. 登録日 2023-02-06 公開日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nat Commun, 14, 2023
6V03	ELIC-propylammonium complex in POPC-only nanodiscs 分子名称: 3-AMINOPROPANE, Gamma-aminobutyric-acid receptor subunit beta-1 著者 Grosman, C, Kumar, P. 登録日 2019-11-18 公開日 2020-01-15 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer. Proc.Natl.Acad.Sci.USA, 117, 2020
7WUQ	Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 分子名称: Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Q.T, Guo, S.C, Xiao, P, Sun, J.P, Yu, X, Gou, L, Kong, L.L, Zhang, L. 登録日 2022-02-09 公開日 2022-04-27 最終更新日 2022-05-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
8KH5	Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8IED	Cryo-EM structure of GPR156-miniGo-scFv16 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... 著者 Shin, J, Park, J, Cho, Y. 登録日 2023-02-15 公開日 2024-02-14 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Constitutive activation mechanism of a class C GPCR. Nat.Struct.Mol.Biol., 31, 2024
7WUI	Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 分子名称: Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Guo, S.C, He, Q.T, Xiao, P, Sun, J.P, Yu, X. 登録日 2022-02-08 公開日 2022-04-27 最終更新日 2022-05-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
7WUJ	Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 分子名称: Adhesion G-protein coupled receptor G4,Uncharacterized protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Guo, S.C, Huang, S.M, He, Q.T, Xiao, P, Sun, J.P, Yu, X. 登録日 2022-02-08 公開日 2022-04-27 最終更新日 2022-05-11 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
7WU9	Cryo-EM structure of the human EP3-Gi signaling complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T. 登録日 2022-02-07 公開日 2022-08-17 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.375 Å) 主引用文献 Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex. Cell Rep, 40, 2022
8JPD	Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes 分子名称: Beta-adrenergic receptor kinase 1, STAUROSPORINE 著者 Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. 登録日 2023-06-11 公開日 2023-08-09 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
1CNL	ALPHA-CONOTOXIN IMI 分子名称: PROTEIN (ALPHA-CONOTOXIN IMI) 著者 Gehrmann, J, Daly, N.L, Craik, D.J. 登録日 1999-05-20 公開日 1999-05-27 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance. J.Med.Chem., 42, 1999
7X2V	GPR110/Gi complex 分子名称: Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Zhu, X. 登録日 2022-02-26 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
1CMR	NMR SOLUTION STRUCTURE OF A CHIMERIC PROTEIN, DESIGNED BY TRANSFERRING A FUNCTIONAL SNAKE BETA-HAIRPIN INTO A SCORPION ALPHA/BETA SCAFFOLD (PH 3.5, 20C), NMR, 18 STRUCTURES 分子名称: CHARYBDOTOXIN, ALPHA CHIMERA 著者 Zinn-Justin, S, Guenneugues, M, Drakopoulou, E, Gilquin, B, Vita, C, Menez, A. 登録日 1996-03-15 公開日 1996-08-01 最終更新日 2021-11-03 実験手法 SOLUTION NMR 主引用文献 Transfer of a beta-hairpin from the functional site of snake curaremimetic toxins to the alpha/beta scaffold of scorpion toxins: three-dimensional solution structure of the chimeric protein. Biochemistry, 35, 1996
7WZ7	GPR110/G12 complex 分子名称: Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Zhu, X. 登録日 2022-02-17 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
7WXU	GPR110/Gq complex 分子名称: Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Zhu, X. 登録日 2022-02-15 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
7WY0	GPR110/G13 complex 分子名称: Adhesion G-protein coupled receptor F1, Engineered G alpha 13 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Zhu, X. 登録日 2022-02-15 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
7WXW	GPR110/Gs complex 分子名称: Adhesion G-protein coupled receptor F1, Engineered mini Galpha-s subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Zhu, X. 登録日 2022-02-15 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022

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