8EAR

Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP

Summary for 8EAR

Entry DOI	10.2210/pdb8ear/pdb
EMDB information	27983
Descriptor	Inositol 1,4,5-trisphosphate receptor type 1, ZINC ION, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	calcium channel, lipid nanodisc, membrane protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	1280721.31
Authors	Fan, G.,Baker, M.R.,Terry, L.E.,Arige, V.,Chen, M.,Seryshev, A.B.,Baker, M.L.,Ludtke, S.J.,Yule, D.I.,Serysheva, I.I. (deposition date: 2022-08-29, release date: 2022-11-23)
Primary citation	Fan, G.,Baker, M.R.,Terry, L.E.,Arige, V.,Chen, M.,Seryshev, A.B.,Baker, M.L.,Ludtke, S.J.,Yule, D.I.,Serysheva, I.I. Conformational motions and ligand-binding underlying gating and regulation in IP 3 R channel. Nat Commun, 13:6942-6942, 2022 Cited by PubMed: 36376291 DOI: 10.1038/s41467-022-34574-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation