PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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3MED	HIV-1 K103N Reverse Transcriptase in Complex with TMC125 分子名称: 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, CHLORIDE ION, SULFATE ION, ... 著者 Lansdon, E.B. 登録日 2010-03-31 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design. J.Med.Chem., 53, 2010
3MEE	HIV-1 Reverse Transcriptase in Complex with TMC278 分子名称: 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, SULFATE ION, p51 Reverse transcriptase, ... 著者 Lansdon, E.B. 登録日 2010-03-31 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design. J.Med.Chem., 53, 2010
3MEG	HIV-1 K103N Reverse Transcriptase in Complex with TMC278 分子名称: 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, SULFATE ION, p51 Reverse transcriptase, ... 著者 Lansdon, E.B. 登録日 2010-03-31 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design. J.Med.Chem., 53, 2010
6WEG	Structure of Ft (MglA-SspA)-ppGpp-PigR peptide complex 分子名称: GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, MglA, ... 著者 Schumacher, M.A, Brennan, R. 登録日 2020-04-02 公開日 2020-11-11 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural Basis for Virulence Activation of Francisella tularensis. Mol.Cell, 81, 2021
2ZNW	Crystal Structure of ScFv10 in Complex with Hen Egg Lysozyme 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Lysozyme C, ScFv10 著者 DeSantis, M.E, Acchione, M, Li, M, Walter, R.L, Wlodawer, A, Smith-Gill, S. 登録日 2008-05-02 公開日 2009-01-27 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics Biochemistry, 51, 2012
2ZNX	5-Fluorotryptophan Incorporated ScFv10 Complexed to Hen Egg Lysozyme 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Lysozyme C, ScFv 著者 DeSantis, M.E, Acchione, M, Li, M, Walter, R.L, Wlodawer, A, Smith-Gill, S. 登録日 2008-05-02 公開日 2009-01-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics Biochemistry, 51, 2012
3DLG	Crystal structure of hiv-1 reverse transcriptase in complex with GW564511. 分子名称: N-{4-[amino(dihydroxy)-lambda~4~-sulfanyl]-2-methylphenyl}-2-(4-chloro-2-{[3-fluoro-5-(trifluoromethyl)phenyl]carbonyl}phenoxy)acetamide, P51 RT, PHOSPHATE ION, ... 著者 Ren, J, Chamberlain, P.P, Stammers, D.K. 登録日 2008-06-27 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3DYA	HIV-1 RT with non-nucleoside inhibitor annulated Pyrazole 1 分子名称: 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile, REVERSE TRANSCRIPTASE/RIBONUCLEASE H, p51 RT 著者 Harris, S.F, Villasenor, A. 登録日 2008-07-25 公開日 2008-11-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase J.Med.Chem., 51, 2008
3DOL	Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with GW695634. 分子名称: N-({4-[({4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}acetyl)amino]-3-methylphenyl}sulfonyl)propanamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Chamberlain, P.P, Ren, J, Stammers, D.K. 登録日 2008-07-04 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3DRS	HIV reverse transcriptase K103N mutant in complex with inhibitor R8D 分子名称: 3-chloro-5-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-3-ylmethoxy)phenoxy]benzonitrile, Reverse transcriptase/ribonuclease H, p66 RT 著者 Yan, Y, Prasad, S. 登録日 2008-07-11 公開日 2008-10-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J.Med.Chem., 51, 2008
1HBW	Solution nmr structure of the dimerization domain of the yeast transcriptional activator Gal4 (residues 50-106) 分子名称: REGULATORY PROTEIN GAL4 著者 Hidalgo, P, Ansari, A.Z, Schmidt, P, Hare, B, Simkovic, N, Farrell, S, Shin, E.J, Ptashne, M, Wagner, G. 登録日 2001-04-20 公開日 2001-05-10 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Recruitment of the Transcriptional Machinery Through Gal11P: Structure and Interactions of the GAL4 Dimerization Domain Genes Dev., 15, 2001
3DRR	HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e 分子名称: 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile, Reverse transcriptase/ribonuclease H, p51 RT 著者 Yan, Y. 登録日 2008-07-11 公開日 2008-10-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J.Med.Chem., 51, 2008
3DRP	HIV reverse transcriptase in complex with inhibitor R8e 分子名称: 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile, Reverse transcriptase/ribonuclease H, p51 RT 著者 Yan, Y, Prasad, S. 登録日 2008-07-11 公開日 2008-10-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J.Med.Chem., 51, 2008
3DLE	Crystal structure of hiv-1 reverse transcriptase in complex with GF128590. 分子名称: 2-[4-chloro-2-(phenylcarbonyl)phenoxy]-N-phenylacetamide, Reverse transcriptase/ribonuclease H, p51 RT 著者 Ren, J, Chamberlain, P.P, Stammers, D.K. 登録日 2008-06-27 公開日 2008-08-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3DM2	Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with GW564511. 分子名称: N-{4-[amino(dihydroxy)-lambda~4~-sulfanyl]-2-methylphenyl}-2-(4-chloro-2-{[3-fluoro-5-(trifluoromethyl)phenyl]carbonyl}phenoxy)acetamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Ren, J, Chamberlain, P.P, Stammers, D.K. 登録日 2008-06-30 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3E01	HIV-RT with non-nucleoside inhibitor annulated pyrazole 2 分子名称: 3-[2-bromo-4-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-methylbenzonitrile, Gag-Pol polyprotein 著者 Harris, S.F, Villasenor, A. 登録日 2008-07-30 公開日 2008-11-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase J.Med.Chem., 51, 2008
3DOK	Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248. 分子名称: 2-{4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}-N-(2-methyl-4-sulfamoylphenyl)acetamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Chamberlain, P.P, Ren, J, Stammers, D.K. 登録日 2008-07-04 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3DMJ	CRYSTAL STRUCTURE OF HIV-1 V106A and Y181C MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH GW564511. 分子名称: N-{4-[amino(dihydroxy)-lambda~4~-sulfanyl]-2-methylphenyl}-2-(4-chloro-2-{[3-fluoro-5-(trifluoromethyl)phenyl]carbonyl}phenoxy)acetamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Ren, J, Chamberlain, P.P, Stammers, D.K. 登録日 2008-07-01 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51, 2008
3T1A	Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05 分子名称: 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine, Reverse Transcriptase 著者 Yan, Y, Reid, J. 登録日 2011-07-21 公開日 2011-10-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. J.Med.Chem., 54, 2011
2BX4	Crystal Structure of SARS Coronavirus Main Proteinase (P21212) 分子名称: 3C-like proteinase nsp5 著者 Verschueren, K.H.G, Mesters, J.R, Bigalke, J, Hilgenfeld, R. 登録日 2005-07-22 公開日 2005-09-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses. J.Mol.Biol., 354, 2005
2BX3	Crystal Structure of SARS Coronavirus Main Proteinase (P43212) 分子名称: 3C-like proteinase nsp5 著者 Verschueren, K.H.G, Mesters, J.R, Hilgenfeld, R. 登録日 2005-07-22 公開日 2005-09-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses. J.Mol.Biol., 354, 2005
8CI4	Crystal structure of doubly S-methanethiolated rabbit M-type creatine kinase 分子名称: CITRATE ANION, Creatine kinase M-type 著者 Joergensen, M.H, Andersen, D.G, Andersen, G.R. 登録日 2023-02-08 公開日 2023-12-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Chemical Zymogens and Transmembrane Activation of Transcription in Synthetic Cells. Adv Mater, 36, 2024
7KRJ	The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Wang, Y.-R, Agard, D.A. 登録日 2020-11-20 公開日 2022-01-12 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.56 Å) 主引用文献 Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature, 601, 2021
2R2R	d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment 分子名称: DNA (5'-D(*DAP*DTP*DTP*DAP*DGP*DTP*DTP*DA)-3'), DNA (5'-D(P*DTP*DAP*DAP*DCP*DTP*DAP*DAP*DT)-3'), Reverse transcriptase 著者 Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M. 登録日 2007-08-27 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc.Natl.Acad.Sci.Usa, 105, 2008
2R2U	Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment 分子名称: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide, ... 著者 Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M. 登録日 2007-08-27 公開日 2008-07-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc.Natl.Acad.Sci.Usa, 105, 2008

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