3DOK
Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.
Summary for 3DOK
Entry DOI | 10.2210/pdb3dok/pdb |
Related | 3DLE 3DLG 3DM2 3DMJ 3DOL |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, nnrti, gw678248, drug resistance, hydrolase, transferase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116577.18 |
Authors | Chamberlain, P.P.,Ren, J.,Stammers, D.K. (deposition date: 2008-07-04, release date: 2008-08-12, Last modification date: 2023-08-30) |
Primary citation | Ren, J.,Chamberlain, P.P.,Stamp, A.,Short, S.A.,Weaver, K.L.,Romines, K.R.,Hazen, R.,Freeman, A.,Ferris, R.G.,Andrews, C.W.,Boone, L.,Chan, J.H.,Stammers, D.K. Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. J.Med.Chem., 51:5000-5008, 2008 Cited by PubMed: 18665583DOI: 10.1021/jm8004493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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